Original Research

Early marker for Alzheimer's disease: Hippocampus T1rho (T1ρ) estimation

  1. Mohammad Haris PhD1,*,
  2. Erin McArdle BS1,
  3. Matthew Fenty BS1,
  4. Anup Singh PhD1,
  5. Christos Davatzikos PhD2,
  6. John Q. Trojanowski MD, PhD3,
  7. Elias R. Melhem MD4,
  8. Christopher M. Clark MD5,
  9. Arijitt Borthakur PhD1

Article first published online: 22 APR 2009

DOI: 10.1002/jmri.21735

Issue

Journal of Magnetic Resonance Imaging

Journal of Magnetic Resonance Imaging

Volume 29, Issue 5, pages 1008–1012, May 2009

Additional Information

How to Cite

Haris, M., McArdle, E., Fenty, M., Singh, A., Davatzikos, C., Trojanowski, J. Q., Melhem, E. R., Clark, C. M. and Borthakur, A. (2009), Early marker for Alzheimer's disease: Hippocampus T1rho (T1ρ) estimation. J. Magn. Reson. Imaging, 29: 1008–1012. doi: 10.1002/jmri.21735

Author Information

  1. 1

    MMRRCC, University of Pennsylvania, Philadelphia, Pennsylvania

  2. 2

    SBIA, University of Pennsylvania, Philadelphia, Pennsylvania

  3. 3

    Department of Pathology & Lab Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

  4. 4

    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania

  5. 5

    Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania

*MMRRCC, Department of Radiology, University of Pennsylvania, B1 Stellar-Chance Laboratories, 422 Curie Blvd., Philadelphia, PA 19104-6100

Publication History

  1. Issue published online: 22 APR 2009
  2. Article first published online: 22 APR 2009
  3. Manuscript Accepted: 9 JAN 2009
  4. Manuscript Received: 22 OCT 2008

Funded by

  • Pennsylvania State Tobacco Settlement
  • National Institutes of Health (NIH). Grant Number: NIH RR02305

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Keywords:

  • Alzheimer's disease;
  • hippocampus;
  • MRI;
  • T1rho

Abstract

Purpose

To evaluate the T1rho (T1ρ) MRI relaxation time in hippocampus in the brain of Alzheimer's disease (AD), mild cognitive impairment (MCI), and control, and to determine whether the T1ρ shows any significant difference between these cohorts.

Materials and Methods

With informed consent, AD (n = 49), MCI (n = 48), and age-matched control (n = 31) underwent T1ρ MRI on a Siemens 1.5T Scanner. T1ρ values were automatically calculated from the left and right hippocampus region using in-house developed software. Bonferroni post-hoc multiple comparisons was performed to compare the T1ρ value among the different cohorts.

Results

Significantly higher T1ρ values were observed both in AD (P = 0.000) and MCI (P = 0.037) cohorts compared to control; also, the T1ρ in AD was significantly high over (P = 0.032) MCI. Hippocampus T1ρ was 13% greater in the AD patients than control, while in MCI it was 7% greater than control. Hippocampus T1ρ in AD patients was 6% greater than MCI.

Conclusion

Higher hippocampus T1ρ values in the AD patients might be associated with the increased plaques burden. A follow-up study would help to determine the efficacy of T1ρ values as a predictor of developing AD in the control and MCI individuals. J. Magn. Reson. Imaging 2009;29:1008–1012. © 2009 Wiley-Liss, Inc.

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