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Original Research
Microperfusion-induced elevation of ADC is suppressed after contrast in breast carcinoma
Article first published online: 22 APR 2009
DOI: 10.1002/jmri.21743
Copyright © 2009 Wiley-Liss, Inc.
Additional Information
How to Cite
Yuen, S., Yamada, K., Goto, M., Nishida, K., Takahata, A. and Nishimura, T. (2009), Microperfusion-induced elevation of ADC is suppressed after contrast in breast carcinoma. J. Magn. Reson. Imaging, 29: 1080–1084. doi: 10.1002/jmri.21743
Publication History
- Issue published online: 22 APR 2009
- Article first published online: 22 APR 2009
- Manuscript Accepted: 3 FEB 2009
- Manuscript Received: 18 NOV 2008
- Abstract
- Article
- References
- Cited By
Keywords:
- breast carcinoma;
- magnetic resonance imaging;
- diffusion-weighted imaging;
- apparent diffusion coefficient;
- gadolinium DTPA
Abstract
Purpose
To investigate the effect of gadolinium (Gd)-DTPA on the apparent diffusion coefficient (ADC) of breast carcinoma and to analyze the relationship between pre/postcontrast ADC and the degree of contrast enhancement.
Materials and Methods
Nineteen histopathologically confirmed breast carcinomas (mean size = 22 mm) were analyzed. Their ADCs before and after contrast administration were measured. The contrast-to-noise ratios (CNRs) of the tumors were measured on fat-suppressed 3D T1-weighted images in precontrast, early, and late postcontrast phases. These results were correlated with the measured ADC values.
Results
A significant decrease in the measured ADC was noted after contrast administration (−23%, P = 0.01). Lesions with relatively high ADC before contrast (>1.3 × 10−3 mm2/sec; n = 12) demonstrated a larger degree of ADC reduction (mean 34%) than lesions with low ADC (≤1.3 × 10−3 mm2/sec; n = 7) (mean 4.5%). When an early postcontrast image was used as a surrogate marker of malignant potential, we found a significant inverse correlation with postcontrast ADC (γ = −0.57, P = 0.02).
Conclusion
Postcontrast ADC exhibited lower values than precontrast ADC, which is thought to reflect suppression of the microperfusion-induced effect on diffusion-weighted imaging. Postcontrast ADC may be a better indicator than precontrast ADC to reflect malignant potential of tumors. J. Magn. Reson. Imaging 2009;29:1080–1084. © 2009 Wiley-Liss, Inc.