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Clinical Note
Diminished visibility of cerebral venous vasculature in multiple sclerosis by susceptibility-weighted imaging at 3.0 Tesla
Article first published online: 22 APR 2009
DOI: 10.1002/jmri.21758
Copyright © 2009 Wiley-Liss, Inc.
Additional Information
How to Cite
Ge, Y., Zohrabian, V. M., Osa, E.-O., Xu, J., Jaggi, H., Herbert, J., Haacke, E. M. and Grossman, R. I. (2009), Diminished visibility of cerebral venous vasculature in multiple sclerosis by susceptibility-weighted imaging at 3.0 Tesla. J. Magn. Reson. Imaging, 29: 1190–1194. doi: 10.1002/jmri.21758
Publication History
- Issue published online: 22 APR 2009
- Article first published online: 22 APR 2009
- Manuscript Accepted: 6 FEB 2009
- Manuscript Received: 23 OCT 2008
Funded by
- National Institute of Health. Grant Number: R01NS029029-16
- state of Michigan. Grant Number: #085P5200251
- Multiple Sclerosis Society. Grant Number: #CA1042-A-8
- Abstract
- Article
- References
- Cited By
Keywords:
- multiple sclerosis;
- magnetic resonance;
- susceptibility-weighted imaging;
- oxygenation;
- venography
Abstract
Multiple sclerosis (MS) is a disease of the central nervous system characterized by widespread demyelination, axonal loss and gliosis, and neurodegeneration; susceptibility-weighted imaging (SWI), through the use of phase information to enhance local susceptibility or T2* contrast, is a relatively new and simple MRI application that can directly image cerebral veins by exploiting venous blood oxygenation. Here, we use high-field SWI at 3.0 Tesla to image 15 patients with clinically definite relapsing-remitting MS and to assess cerebral venous oxygen level changes. We demonstrate significantly reduced visibility of periventricular white matter venous vasculature in patients as compared to control subjects, supporting the concept of a widespread hypometabolic MS disease process. SWI may afford a noninvasive and relatively simple method to assess venous oxygen saturation so as to closely monitor disease severity, progression, and response to therapy. J. Magn. Reson. Imaging 2009;29:1190–1194. © 2009 Wiley-Liss, Inc.