Feasibility and reproducibility of biventricular volumetric assessment of cardiac function during exercise using real-time radial k-t SENSE magnetic resonance imaging

Authors

  • Philipp Lurz MD,

    1. UCL Institute of Child Health, London, UK
    2. Great Ormond Street Hospital for Children NHS Trust, Cardiothoracic Unit, London, UK
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  • Vivek Muthurangu MD,

    1. UCL Institute of Child Health, London, UK
    2. Great Ormond Street Hospital for Children NHS Trust, Cardiothoracic Unit, London, UK
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  • Silvia Schievano PhD,

    1. UCL Institute of Child Health, London, UK
    2. Great Ormond Street Hospital for Children NHS Trust, Cardiothoracic Unit, London, UK
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  • Johannes Nordmeyer MD,

    1. UCL Institute of Child Health, London, UK
    2. Great Ormond Street Hospital for Children NHS Trust, Cardiothoracic Unit, London, UK
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  • Philipp Bonhoeffer MD,

    1. UCL Institute of Child Health, London, UK
    2. Great Ormond Street Hospital for Children NHS Trust, Cardiothoracic Unit, London, UK
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  • Andrew M. Taylor MD,

    Corresponding author
    1. UCL Institute of Child Health, London, UK
    2. Great Ormond Street Hospital for Children NHS Trust, Cardiothoracic Unit, London, UK
    • Cardiovascular Unit, Great Ormond Street Hospital, Great Ormond St., London WC1N 3JH, UK
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  • Michael S. Hansen PhD

    1. UCL Institute of Child Health, London, UK
    2. Great Ormond Street Hospital for Children NHS Trust, Cardiothoracic Unit, London, UK
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Abstract

Purpose

To assess the feasibility and reproducibility of real-time radial k-t sensitivity encoding (SENSE) magnetic resonance imaging (MRI) for biventricular volumetric assessment during exercise.

Materials and Methods

In all, 12 healthy young adults underwent MRI at rest and during supine exercise at three different workload intensities. Biventricular volumes and function were assessed with 1) a radial k-t SENSE real-time sequence and 2) a scanner vendor supplied (standard) real-time sequence. Global image quality, motion fidelity, and agreement in right ventricular (RV) and left ventricular (LV) stroke volume (SV) as a surrogate measure for accuracy were assessed. Exercise MR was repeated within 1 month for assessment of reproducibility.

Results

Imaging scores were superior for radial real-time k-t SENSE images (P < 0.001). Agreement in RV and LV SV during exercise was better with radial k-t real-time (SD of difference ±3.43 vs. ±8.97 mL; P < 0.001). Agreement in cardiac output (CO) in the same subject at two different imaging sessions was better for radial k-t SENSE. This was significant for the CO calculated for the RV (SD of difference ±0.6 vs. ±0.95 L/min; P = 0.01) and LV (±0.45 vs. ±0.92 L/min; P < 0.001).

Conclusion

Radial k-t SENSE real-time imaging represents a feasible and reproducible imaging technique for biventricular assessment during exercise. J. Magn. Reson. Imaging 2009;29:1062–1070. © 2009 Wiley-Liss, Inc.

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