Automated assessment of whole-body adipose tissue depots from continuously moving bed MRI: A feasibility study
Article first published online: 25 JUN 2009
Copyright © 2009 Wiley-Liss, Inc.
Journal of Magnetic Resonance Imaging
Volume 30, Issue 1, pages 185–193, July 2009
How to Cite
Kullberg, J., Johansson, L., Ahlström, H., Courivaud, F., Koken, P., Eggers, H. and Börnert, P. (2009), Automated assessment of whole-body adipose tissue depots from continuously moving bed MRI: A feasibility study. J. Magn. Reson. Imaging, 30: 185–193. doi: 10.1002/jmri.21820
- Issue published online: 25 JUN 2009
- Article first published online: 25 JUN 2009
- Manuscript Accepted: 15 APR 2009
- Manuscript Received: 26 JAN 2009
- Swedish Research Council. Grant Number: K2006-71X-06676-24-3
- Philips Healthcare
- magnetic resonance imaging;
- water–fat imaging;
- visceral adipose tissue;
- subcutaneous adipose tissue;
- automated segmentation
To present an automated algorithm for segmentation of visceral, subcutaneous, and total volumes of adipose tissue depots (VAT, SAT, TAT) from whole-body MRI data sets and to investigate the VAT segmentation accuracy and the reproducibility of all depot assessments.
Materials and Methods
Repeated measurements were performed on 24 volunteer subjects using a 1.5 Tesla clinical MRI scanner and a three-dimensional (3D) multi-gradient-echo sequence (resolution: 2.1 × 2.1 × 8 mm3, acquisition time: 5 min 15 s). Fat and water images were reconstructed, and fully automated segmentation was performed. Manual segmentation of the VAT reference was performed by an experienced operator.
Strong correlation (R = 0.999) was found between the automated and manual VAT assessments. The automated results underestimated VAT with 4.7 ± 4.4%. The accuracy was 88 ± 4.5% and 7.6 ± 5.7% for true positive and false positive fractions, respectively. Coefficients of variation from the repeated measurements were: 2.32 % ± 2.61%, 2.25% ± 2.10%, and 1.01% ± 0.74% for VAT, SAT, and TAT, respectively.
Automated and manual VAT results correlated strongly. The assessments of all depots were highly reproducible. The acquisition and postprocessing techniques presented are likely useful in obesity related studies. J. Magn. Reson. Imaging 2009;30:185–193. © 2009 Wiley-Liss, Inc.