Original Research

PC HYPR flow: A technique for rapid imaging of contrast dynamics

  1. Julia V. Velikina PhD1,*,
  2. Kevin M. Johnson PhD1,
  3. Yijing Wu PhD1,
  4. Alexey A. Samsonov PhD2,
  5. Patrick Turski MD2,
  6. Charles A. Mistretta PhD1,2

Article first published online: 23 JAN 2010

DOI: 10.1002/jmri.22035

Issue

Journal of Magnetic Resonance Imaging

Journal of Magnetic Resonance Imaging

Volume 31, Issue 2, pages 447–456, February 2010

Additional Information

How to Cite

Velikina, J. V., Johnson, K. M., Wu, Y., Samsonov, A. A., Turski, P. and Mistretta, C. A. (2010), PC HYPR flow: A technique for rapid imaging of contrast dynamics. J. Magn. Reson. Imaging, 31: 447–456. doi: 10.1002/jmri.22035

Author Information

  1. 1

    Department of Medical Physics, University of Wisconsin, Madison, Wisconsin, USA

  2. 2

    Department of Radiology, University of Wisconsin, Madison, Wisconsin, USA

*University of Wisconsin – Madison, Department of Medical Physics, 1111 Highland Avenue, Madison, WI 53792-3252

Publication History

  1. Issue published online: 23 JAN 2010
  2. Article first published online: 23 JAN 2010
  3. Manuscript Accepted: 28 OCT 2009
  4. Manuscript Received: 4 MAY 2009

Funded by

  • NIH. Grant Numbers: RO1HL/RR6648803A1, R01CA116380, R21EB009441, R21EB006393
  • GE Healthcare

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Keywords:

  • constrained reconstruction;
  • contrast enhanced MRA;
  • phase contrast MRA;
  • HYPR;
  • angiography;
  • radial trajectory

Abstract

Purpose:

To improve spatial and temporal resolution and signal-to-noise ratio (SNR) in three-dimensional (3D) radial contrast-enhanced (CE) time-resolved MR angiography by means of a novel hybrid phase contrast (PC) and CE MRA acquisition and HYPR reconstruction (PC HYPR Flow).

Materials and Methods:

PC HYPR Flow consists of a CE exam immediately followed by a PC scan used to constrain the HYPR reconstruction of the time series. Temporal resolution of the new method was studied in computer simulations. The feasibility of the new technique was studied in healthy subjects and patients with brain arteriovenous malformations and in a canine model of aneurysms.

Results:

Simulations demonstrated preservation of contrast agent dynamics in proximal vessels, showing better performance than peer methods for acceleration up to 20 in 2D. In vivo, PC HYPR Flow yielded 3D time series with frame rate of 0.5 s and significantly outperformed two peer methods by means of a major increase in spatial resolution (0.8 × 0.8 × 0.8 mm3) and arterial/venous ratio, while maintaining necessary temporal waveform fidelity and high SNR.

Conclusion:

This initial study indicates that PC HYPR Flow simultaneously provides 3D isotropic sub-millimeter spatial resolution, sub-second temporal reconstruction windows and high SNR level, which may benefit a wide range of CE MRA applications. J. Magn. Reson. Imaging 2010; 31: 447–456. © 2010 Wiley-Liss, Inc.

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