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Original Research
Improved blood suppression in three-dimensional (3D) fast spin-echo (FSE) vessel wall imaging using a combination of double inversion-recovery (DIR) and diffusion sensitizing gradient (DSG) preparations
Article first published online: 23 JAN 2010
DOI: 10.1002/jmri.22042
Copyright © 2010 Wiley-Liss, Inc.
Additional Information
How to Cite
Makhijani, M. K., Hu, H. H., Pohost, G. M. and Nayak, K. S. (2010), Improved blood suppression in three-dimensional (3D) fast spin-echo (FSE) vessel wall imaging using a combination of double inversion-recovery (DIR) and diffusion sensitizing gradient (DSG) preparations. J. Magn. Reson. Imaging, 31: 398–405. doi: 10.1002/jmri.22042
Publication History
- Issue published online: 23 JAN 2010
- Article first published online: 23 JAN 2010
- Manuscript Accepted: 2 NOV 2009
- Manuscript Received: 6 JUL 2009
Funded by
- University of Southern California (USC) Clinical Translational Science Institute
- Abstract
- Article
- References
- Cited By
Keywords:
- carotid;
- vessel wall;
- black-blood;
- inner volume imaging;
- diffusion sensitizing gradients;
- double inversion recovery
Abstract
Purpose:
To provide improved blood suppression in three-dimensional inner-volume fast spin-echo (3D IV-FSE) carotid vessel wall imaging by using a hybrid preparation consisting of double inversion-recovery (DIR) and diffusion sensitizing gradients (DSG).
Materials and Methods:
Multicontrast black-blood MRI is widely used for vessel wall imaging and characterization of atherosclerotic plaque composition. Blood suppression is difficult when using 3D volumetric imaging techniques. DIR approaches do not provide robust blood suppression due to incomplete replacement of blood spins, and DSG approaches compromise vessel wall signal, reducing the lumen-wall contrast-to-noise ratio efficiency (CNReff). In this work a hybrid DIR+DSG preparation is developed and optimized for blood suppression, vessel wall signal preservation, and vessel-wall contrast in 3D IV-FSE imaging. Cardiac gated T1-weighted carotid vessel wall images were acquired in five volunteers with 0.5 × 0.5 × 2.5 mm3 spatial resolution in 80 seconds.
Results:
Data from healthy volunteers indicate that the proposed method yields a statistically significant (P < 0.01) improvement in blood suppression and lumen-wall CNReff compared to standard DIR and standard DSG methods alone.
Conclusion:
A combination of DIR and DSG preparations can provide improved blood suppression and lumen-wall CNReff for 3D IV-FSE vessel wall imaging. J. Magn. Reson. Imaging 2010; 31: 398–405. © 2010 Wiley-Liss, Inc.