Study of the features of proton MR spectroscopy (1H-MRS) on amyotrophic lateral sclerosis

Authors


Abstract

Purpose:

To study the features of proton magnetic resonance spectroscopy (1H-MRS) on amyotrophic lateral sclerosis (ALS) and its relation with clinical scale.

Materials and Methods:

Fifteen patients with definite or probable ALS and 15 age- and gender-matched normal controls were enrolled. 1H-MRS was performed on a 3.0 Tesla GE imaging system (GE Healthcare, Milwaukee, WI). TE-averaged Point Resolved Selective Spectroscopy was used. N-acetylaspartate (NAA), creatine (Cr), Glu, and Glx (glutamate + glutamine) values of the motor cortex and posterior limb of internal capsule were acquired. The t-test was used to compare differences between groups, and the correlations between the above values and clinical scale were analyzed.

Results:

The motor area and posterior limb of the internal capsule of ALS patients had lower NAA/Cr (1.91 ± 0.34, 1.53 ± 0.17) compared with normal subjects (2.23 ± 0.33, 1.66 ± 0.07), and the differences between groups were statistically significant (P < 0.01, 0.01). ALS patients had higher Glu/Cr (0.34 ± 0.05, 0.29 ± 0.06) and Glx/Cr (0.40 ± 0.04, 0.33 ± 0.06) compared with normal subjects (0.30 ± 0.03, 0.25 ± 0.04) and (0.32 ± 0.05, 0.26 ± 0.03), and the differences between groups were statistically significant (P < 0.01, 0.01). The Norris scale was negatively correlated with Glx/Cr of primary motor cortex by lineal correlation analysis (r = −0.75), and this correlation had statistical significance (F = 16.60; P = 0.001).

Conclusion:

Neuronal loss and Glu+Gln increase can be detected by using proton MRS in ALS patients. 1H-MRS is an useful tool in reflecting the characteristic changes of metabolite in ALS. J. Magn. Reson. Imaging 2010; 31: 457–465. © 2010 Wiley-Liss, Inc.

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