Original Research

Quantifying in vivo hemodynamic response to exercise in patients with intermittent claudication and abdominal aortic aneurysms using cine phase-contrast MRI

  1. Adam S. Tenforde BA1,
  2. Christopher P. Cheng PhD2,
  3. Ga-Young Suh MS3,
  4. Robert J. Herfkens MD4,
  5. Ronald L. Dalman MD2,
  6. Charles A. Taylor PhD1,2,3,4,*

Article first published online: 23 JAN 2010

DOI: 10.1002/jmri.22055

Issue

Journal of Magnetic Resonance Imaging

Journal of Magnetic Resonance Imaging

Volume 31, Issue 2, pages 425–429, February 2010

Additional Information

How to Cite

Tenforde, A. S., Cheng, C. P., Suh, G.-Y., Herfkens, R. J., Dalman, R. L. and Taylor, C. A. (2010), Quantifying in vivo hemodynamic response to exercise in patients with intermittent claudication and abdominal aortic aneurysms using cine phase-contrast MRI. J. Magn. Reson. Imaging, 31: 425–429. doi: 10.1002/jmri.22055

Author Information

  1. 1

    Department of Bioengineering, Stanford University, Stanford, California, USA

  2. 2

    Department of Surgery, Stanford University, Stanford, California, USA

  3. 3

    Department of Mechanical Engineering, Stanford University, Stanford, California, USA

  4. 4

    Department of Radiology, Stanford University, Stanford, California, USA

*Department of Bioengineering, Stanford University, James H. Clark Center, 318 Campus Drive, E350B, Stanford, CA 94305

Publication History

  1. Issue published online: 23 JAN 2010
  2. Article first published online: 23 JAN 2010
  3. Manuscript Accepted: 30 OCT 2009
  4. Manuscript Received: 8 AUG 2009

Funded by

  • National Institutes of Health. Grant Numbers: P50 HL083800, P41 RR09784, R01 HL064338

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Keywords:

  • exercise imaging;
  • blood flow;
  • vascular disease;
  • abdominal aortic aneurysm;
  • phase-contrast MRI

Abstract

Purpose:

To evaluate rest and exercise hemodynamics in patients with abdominal aortic aneurysms (AAA) and peripheral occlusive disease (claudicants) using phase-contrast MRI.

Materials and Methods:

Blood velocities were acquired by means of cardiac-gated cine phase-contrast in a 0.5 Tesla (T) open MRI. Volumetric flow was calculated at the supraceliac (SC), infrarenal (IR), and mid-aneurysm (MA) levels during rest and upright cycling exercise using an MR-compatible exercise cycle.

Results:

Mean blood flow increased during exercise (AAA: 130%, Claudicants: 136% of resting heart rate) at the SC and IR levels for AAA participants (2.6 ± 0.6 versus 5.8 ± 1.6 L/min, P < 0.001 and 0.8 ± 0.4 versus 5.1 ± 1.7 L/min, P < 0.001) and claudicants (2.3 ± 0.5 versus 4.5 ± 0.9 L/min, P < 0.005 and 0.8 ± 0.2 versus 3.3 ± 0.9 L/min, P < 0.005). AAA participants had a significant decrease in renal and digestive blood flow from rest to exercise (1.8 ± 0.7 to 0.7 ± 0.6 L/min, P < 0.01). The decrease in renal and digestive blood flow during exercise correlated with daily activity level for claudicants (R = 0.81).

Conclusion:

Abdominal aortic hemodynamic changes due to lower extremity exercise can be quantified in patients with AAA and claudication using PC-MRI. The redistribution of blood flow during exercise was significant and different between the two disease states. J. Magn. Reson. Imaging 2010; 31: 425–429. © 2010 Wiley-Liss, Inc.

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