Detection of hepatic hypovascular metastases: 3D gradient echo MRI using a hepatobiliary contrast agent

Authors

  • Jin-Young Choi MD,

    1. Department of Radiology, Research Institute of Radiological Science, Yonsei University Health System, Seoul, Republic of Korea
    2. Institute of Gastroenterology, Yonsei University Health System and Brain Korea 21 project, Seoul, Republic of Korea
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  • Jin-Sub Choi MD,

    1. Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea
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  • Myeong-Jin Kim MD,

    Corresponding author
    1. Department of Radiology, Research Institute of Radiological Science, Yonsei University Health System, Seoul, Republic of Korea
    2. Institute of Gastroenterology, Yonsei University Health System and Brain Korea 21 project, Seoul, Republic of Korea
    • Department of Diagnostic Radiology, Yonsei University College of Medicine, Seodaemun-ku Shinchon-dong 134, Seoul, 120-752, Republic of Korea
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  • Joon Seok Lim MD,

    1. Department of Radiology, Research Institute of Radiological Science, Yonsei University Health System, Seoul, Republic of Korea
    2. Institute of Gastroenterology, Yonsei University Health System and Brain Korea 21 project, Seoul, Republic of Korea
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  • Mi Suk Park MD,

    1. Department of Radiology, Research Institute of Radiological Science, Yonsei University Health System, Seoul, Republic of Korea
    2. Institute of Gastroenterology, Yonsei University Health System and Brain Korea 21 project, Seoul, Republic of Korea
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  • Joo Hee Kim MD,

    1. Department of Radiology, Research Institute of Radiological Science, Yonsei University Health System, Seoul, Republic of Korea
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  • Yong Eun Chung MD

    1. Department of Radiology, Research Institute of Radiological Science, Yonsei University Health System, Seoul, Republic of Korea
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Abstract

Purpose:

To assess the diagnostic performance of gadobenate dimeglumine-enhanced 3D gradient echo (3D-GRE) magnetic resonance imaging (MRI) for the detection of hepatic hypovascular metastases.

Materials and Methods:

We retrospectively analyzed the initial radiologic reports of MRI of 41 patients with suspected hepatic metastases. Seventy-nine metastatic lesions were confirmed by histopathology or intraoperative ultrasound (IOUS). The sensitivity and positive predictive values for the diagnosis of hepatic metastasis were determined among each MRI set (hepatobiliary phase, precontrast images, dynamic imaging). The diagnostic performance of dynamic image set and combined dynamic and hepatobiliary image set was also evaluated by two radiologists using alternative free response receiver operating characteristic (ROC) analysis.

Results:

The overall detection rate and positive predictive value of MR were 96.2% (76/79) and 96.2% (76/79), respectively. Images obtained with hepatobiliary phase 3D-GRE showed a significantly better detection rate compared to those with precontrast sequences or dynamic imaging (P = 0.008 and 0.016, respectively). Regarding lesions 1 cm or smaller, the detection rate was 90.3% (28/31). Each reader showed a higher Az value of the combined hepatobiliary image set than those of the dynamic image set.

Conclusion:

3D-GRE MRI using a hepatobiliary contrast agent is an accurate tool in the detection of hepatic hypovascular metastases and improves detection rate compared with precontrast and dynamic imaging. J. Magn. Reson. Imaging 2010;31:571–578. © 2010 Wiley-Liss, Inc.

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