Detection of hepatic hypovascular metastases: 3D gradient echo MRI using a hepatobiliary contrast agent
Article first published online: 25 FEB 2010
Copyright © 2010 Wiley-Liss, Inc.
Journal of Magnetic Resonance Imaging
Volume 31, Issue 3, pages 571–578, March 2010
How to Cite
Choi, J.-Y., Choi, J.-S., Kim, M.-J., Lim, J. S., Park, M. S., Kim, J. H. and Chung, Y. E. (2010), Detection of hepatic hypovascular metastases: 3D gradient echo MRI using a hepatobiliary contrast agent. J. Magn. Reson. Imaging, 31: 571–578. doi: 10.1002/jmri.22076
- Issue published online: 25 FEB 2010
- Article first published online: 25 FEB 2010
- Manuscript Accepted: 2 DEC 2009
- Manuscript Received: 14 JUL 2009
- Yonsei University College of Medicine Research Fund of 2007
- magnetic resonance imaging;
- contrast agent;
- gadobenate dimeglumine
To assess the diagnostic performance of gadobenate dimeglumine-enhanced 3D gradient echo (3D-GRE) magnetic resonance imaging (MRI) for the detection of hepatic hypovascular metastases.
Materials and Methods:
We retrospectively analyzed the initial radiologic reports of MRI of 41 patients with suspected hepatic metastases. Seventy-nine metastatic lesions were confirmed by histopathology or intraoperative ultrasound (IOUS). The sensitivity and positive predictive values for the diagnosis of hepatic metastasis were determined among each MRI set (hepatobiliary phase, precontrast images, dynamic imaging). The diagnostic performance of dynamic image set and combined dynamic and hepatobiliary image set was also evaluated by two radiologists using alternative free response receiver operating characteristic (ROC) analysis.
The overall detection rate and positive predictive value of MR were 96.2% (76/79) and 96.2% (76/79), respectively. Images obtained with hepatobiliary phase 3D-GRE showed a significantly better detection rate compared to those with precontrast sequences or dynamic imaging (P = 0.008 and 0.016, respectively). Regarding lesions 1 cm or smaller, the detection rate was 90.3% (28/31). Each reader showed a higher Az value of the combined hepatobiliary image set than those of the dynamic image set.
3D-GRE MRI using a hepatobiliary contrast agent is an accurate tool in the detection of hepatic hypovascular metastases and improves detection rate compared with precontrast and dynamic imaging. J. Magn. Reson. Imaging 2010;31:571–578. © 2010 Wiley-Liss, Inc.