Modified brix model analysis of bone perfusion in subjects of varying bone mineral density
Article first published online: 23 APR 2010
Copyright © 2010 Wiley-Liss, Inc.
Journal of Magnetic Resonance Imaging
Volume 31, Issue 5, pages 1169–1175, May 2010
How to Cite
Ma, H. T., Griffith, J. F., Yeung, D. K. and Leung, P.C. (2010), Modified brix model analysis of bone perfusion in subjects of varying bone mineral density. J. Magn. Reson. Imaging, 31: 1169–1175. doi: 10.1002/jmri.22164
- Issue published online: 23 APR 2010
- Article first published online: 23 APR 2010
- Manuscript Accepted: 9 FEB 2010
- Manuscript Received: 6 NOV 2009
- the Research Grants Council of the Hong Kong Special Administrative Region, China. Grant Number: 464508
- bone perfusion;
- pharmacokinetic model;
To apply pharmacokinetic modeling to the investigation of bone perfusion in subjects of varying bone mineral density.
Materials and Methods:
This study re-analyzed previous experimental data. A modified pharmacokinetic model was applied to data obtained from two prior studies of dynamic contrast-enhanced MR imaging of L3 vertebral body in 165 subjects (65 males, 100 females), classified into three groups (normal, osteopenia, and osteoporosis) according to bone mineral density. Three parameters, amplitude A, exchange rate (kep), and elimination rate (kel), were obtained by fitting the signal intensity to the pharmacokinetic model. These parameters were compared across the three groups for males and females, respectively.
Perfusion parameters, amplitude A was found to be reduced in osteoporotic subjects with additional, though less pronounced, reductions found in the permeability constant (A*kep) and the elimination rate (kel). Increased marrow fat content was found in osteoporotic bone, which helped to partially explain the observed reduction in interstitial space.
By pharmacokinetic model, bone perfusion can be quantitatively analyzed with alteration in functional parameters related to microcirculation in subjects of varying bone mineral density. Developing bone marrow specific pharmacokinetic models should help to deepen knowledge of physiological and pathological perfusion changes occurring in bone. J. Magn. Reson. Imaging 2010;31:1169–1175. © 2010 Wiley-Liss, Inc.