In vivo vascular hallmarks of diffuse leukoaraiosis
Article first published online: 23 JUN 2010
Copyright © 2010 Wiley-Liss, Inc.
Journal of Magnetic Resonance Imaging
Volume 32, Issue 1, pages 184–190, July 2010
How to Cite
Uh, J., Yezhuvath, U., Cheng, Y. and Lu, H. (2010), In vivo vascular hallmarks of diffuse leukoaraiosis. J. Magn. Reson. Imaging, 32: 184–190. doi: 10.1002/jmri.22209
- Issue published online: 23 JUN 2010
- Article first published online: 23 JUN 2010
- Manuscript Accepted: 30 MAR 2010
- Manuscript Received: 22 NOV 2009
- Alzheimer Association. Grant Number: NIRG 05-14056
- National Institutes of Health (NIH). Grant Numbers: NIH R01 MH084021, NIH R21 NS054916, NIH P30 AG12300
- American Heart Association
- Texas Instruments Foundation
- vascular changes;
- cerebral blood flow;
- cerebrovascular reactivity;
To characterize multiple patterns of vascular changes in leukoaraiosis using in vivo magnetic resonance imaging (MRI) techniques.
Materials and Methods:
We measured cerebral blood flow (CBF), cerebrovascular reactivity (CVR), and blood–brain-barrier (BBB) leakage in a group of 33 elderly subjects (age: 72.3 ± 6.8 years, 17 males, 16 females). Leukoaraiosis brain regions were identified in each subject using fluid-attenuated inversion-recovery (FLAIR) MRI. Vascular parameters in the leukoaraiosis regions were compared to those in the normal-appearing white matter (NAWM) regions. Vascular changes in leukoaraiosis were also compared to structural damage as assessed by diffusion tensor imaging.
CBF and CVR in leukoaraiosis regions were found to be 39.7 ± 5.2% (P < 0.001) and 52.5 ± 11.6% (P = 0.005), respectively, of those in NAWM. In subjects who did not have significant leukoaraiosis, CBF and CVR in regions with high risk for leukoaraiosis showed a slight reduction compared to the other white matter regions. Significant BBB leakage was also detected (P = 0.003) in leukoaraiosis and the extent of BBB leakage was positively correlated with mean diffusivity. In addition, CVR in NAWM was lower than that in white matter of subjects without significant leukoaraiosis.
Leukoaraiosis was characterized by reduced CBF, CVR, and a leakage in the BBB. J. Magn. Reson. Imaging 2010;32:184–190. © 2010 Wiley-Liss, Inc.