Comparison of k-t SENSE/k-t BLAST with conventional SENSE applied to BOLD fMRI
Article first published online: 23 JUN 2010
Copyright © 2010 Wiley-Liss, Inc.
Journal of Magnetic Resonance Imaging
Volume 32, Issue 1, pages 235–241, July 2010
How to Cite
Utting, J. F., Kozerke, S., Schnitker, R. and Niendorf, T. (2010), Comparison of k-t SENSE/k-t BLAST with conventional SENSE applied to BOLD fMRI. J. Magn. Reson. Imaging, 32: 235–241. doi: 10.1002/jmri.22212
- Issue published online: 23 JUN 2010
- Article first published online: 23 JUN 2010
- Manuscript Accepted: 1 APR 2010
- Manuscript Received: 9 OCT 2009
- k-t BLAST/k-t SENSE;
- parallel imaging;
- 3 Tesla;
- fast spin echo
To compare k-t BLAST (broad-use linear-acquisition speedup technique)/k-t SENSE (sensitivity encoding) with conventional SENSE applied to a simple fMRI paradigm.
Materials and Methods:
Blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) was performed at 3 T using a displaced ultra-fast low-angle refocused echo (UFLARE) pulse sequence with a visual stimulus in a block paradigm. Conventional SENSE and k-t BLAST/k-t SENSE data were acquired. Also, k-t BLAST/k-t SENSE was simulated at different undersampling factors from fully sampled data after removal of lines of k-space data. Analysis was performed using SPM5.
Sensitivity to the BOLD response in k-t BLAST/k-t SENSE was comparable with that of SENSE in images acquired at an undersampling factor of 2.3. Simulated k-t BLAST/k-t SENSE yielded reliable detection of activation-induced BOLD contrast at undersampling factors of 5 or less. Sensitivity increased significantly when training data were included in k-space before Fourier transformation (known as “plug-in”).
k-t BLAST/k-t SENSE performs at least as well as conventional SENSE for BOLD fMRI at a modest undersampling factor. Results suggest that sufficient sensitivity to BOLD contrast may be achievable at higher undersampling factors with k-t BLAST/k-t SENSE than with conventional parallel imaging approaches, offering particular advantages at the highest magnetic field strengths. J. Magn. Reson. Imaging 2010;32:235–241. © 2010 Wiley-Liss, Inc.