Comparison of k-t SENSE/k-t BLAST with conventional SENSE applied to BOLD fMRI

Authors

  • Jane F. Utting PhD,

    Corresponding author
    1. Division of Experimental Magnetic Resonance Imaging, Department of Diagnostic Radiology, Faculty of Medicine, RWTH-Aachen, Aachen, Germany
    2. Department of Medical Physics, NHS Grampian, Aberdeen, UK
    3. Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, UK
    • Principal Physicist, MRI, Lilian Sutton Building, Aberdeen Royal Infirmary, Foresterhill Rd., Aberdeen, AB25 2ZD, United Kingdom
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  • Sebastian Kozerke PhD,

    1. Institute for Biomedical Engineering, University and ETH Zurich, Switzerland
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  • Ralph Schnitker PhD,

    1. IZKF-BIOMAT, Faculty of Medicine, RWTH-Aachen, Aachen, Germany
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  • Thoralf Niendorf PhD

    1. Division of Experimental Magnetic Resonance Imaging, Department of Diagnostic Radiology, Faculty of Medicine, RWTH-Aachen, Aachen, Germany
    2. Faculty of Mathematics, Computerscience and Natural Science, RWTH-Aachen, Aachen, Germany
    3. Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine, Berlin, Germany
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Abstract

Purpose:

To compare k-t BLAST (broad-use linear-acquisition speedup technique)/k-t SENSE (sensitivity encoding) with conventional SENSE applied to a simple fMRI paradigm.

Materials and Methods:

Blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) was performed at 3 T using a displaced ultra-fast low-angle refocused echo (UFLARE) pulse sequence with a visual stimulus in a block paradigm. Conventional SENSE and k-t BLAST/k-t SENSE data were acquired. Also, k-t BLAST/k-t SENSE was simulated at different undersampling factors from fully sampled data after removal of lines of k-space data. Analysis was performed using SPM5.

Results:

Sensitivity to the BOLD response in k-t BLAST/k-t SENSE was comparable with that of SENSE in images acquired at an undersampling factor of 2.3. Simulated k-t BLAST/k-t SENSE yielded reliable detection of activation-induced BOLD contrast at undersampling factors of 5 or less. Sensitivity increased significantly when training data were included in k-space before Fourier transformation (known as “plug-in”).

Conclusion:

k-t BLAST/k-t SENSE performs at least as well as conventional SENSE for BOLD fMRI at a modest undersampling factor. Results suggest that sufficient sensitivity to BOLD contrast may be achievable at higher undersampling factors with k-t BLAST/k-t SENSE than with conventional parallel imaging approaches, offering particular advantages at the highest magnetic field strengths. J. Magn. Reson. Imaging 2010;32:235–241. © 2010 Wiley-Liss, Inc.

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