Reproducibility and correlation between quantitative and semiquantitative dynamic and intrinsic susceptibility-weighted MRI parameters in the benign and malignant human prostate




To assess the reproducibility of relaxivity- and susceptibility-based dynamic contrast-enhanced magnetic resonance imaging (MRI) in the benign and malignant prostate gland and to correlate the kinetic parameters obtained.

Materials and Methods:

Twenty patients with prostate cancer underwent paired scans before and after androgen deprivation therapy. Quantitative parametric maps for T1- and T2*-weighted parameters were calculated (Ktrans, kep,ve, IAUC60, rBV, rBF, and R2*). The reproducibility of and correlation between each parameter were determined using standard methods at both timepoints.


T1-derived parameters are more reproducible than T2*-weighted measures, both becoming more variable following androgen deprivation (variance coefficients for prostate Ktrans and rBF increased from 13.9%–15.8% and 42.5%–90.8%, respectively). Tumor R2* reproducibility improved after androgen ablation (23.3%–11.8%). IAUC60 correlated strongly with Ktrans, ve, and kep (all P < 0.001). R2* did not correlate with other parameters.


This study is the first to document the variability and repeatability of T1- and T2*-weighted dynamic MRI and intrinsic susceptibility-weighted MRI for the various regions of the human prostate gland before and after androgen deprivation. These data provide a valuable source of reference for groups that plan to use dynamic contrast-enhanced MRI or intrinsic susceptibility-weighted MRI for the assessment of treatment response in the benign or malignant prostate. J. Magn. Reson. Imaging 2010;32:155–164. © 2010 Wiley-Liss, Inc.