Cardiac MRI to investigate myocardial scar and coronary venous anatomy using a slow infusion of dimeglumine gadobenate in patients undergoing assessment for cardiac resynchronization therapy
Article first published online: 22 DEC 2010
Copyright © 2010 Wiley-Liss, Inc.
Journal of Magnetic Resonance Imaging
Volume 33, Issue 1, pages 87–95, January 2011
How to Cite
Duckett, S. G., Chiribiri, A., Ginks, M. R., Sinclair, S., Knowles, B. R., Botnar, R., Carr-White, G. S., Rinaldi, C. A., Nagel, E., Razavi, R. and Schaeffter, T. (2011), Cardiac MRI to investigate myocardial scar and coronary venous anatomy using a slow infusion of dimeglumine gadobenate in patients undergoing assessment for cardiac resynchronization therapy. J. Magn. Reson. Imaging, 33: 87–95. doi: 10.1002/jmri.22387
- Issue published online: 22 DEC 2010
- Article first published online: 22 DEC 2010
- Manuscript Accepted: 9 SEP 2010
- Manuscript Received: 10 DEC 2009
- European Community's Seventh Framework Programme. Grant Number: FP7/2007-2013 under grant agreement n. 224495 (euHeart project)
- whole heart MRI;
- coronary vein;
- late enhancement;
To evaluate a cardiac MR (CMR) examination with slow infusion of a high-relaxivity contrast agent to visualize coronary venous anatomy (CVA) and myocardial scar in heart failure patients awaiting cardiac resynchronization therapy (CRT).
Materials and Methods
Fourteen patients awaiting CRT (seven ischemic cardiomyopathy (ICM) and seven non-ICM) and two with normal LV function underwent CMR on a 1.5 Tesla (T) MR scanner. Dimeglumine-gadobenate was slowly infused. Bolus arrival in the LV was measured by a dynamic electrocardiogram (ECG) -triggered inversion recovery (IR) scan subsequent to starting an ECG-triggered respiratory-navigated three-dimensional (3D) SSFP MR scan with IR preparation to acquire systolic whole-heart anatomy for vein visualization. Delayed contrast-enhanced MR scan was performed to assess myocardial scar. CVA obtained by CMR was compared with X-ray venography in 11 patients. CVA and scar were segmented and registered for visual inspection.
For all subjects, there was excellent visualization of the CVA. All ICM and one non-ICM patient showed scar. There was excellent correlation between veins seen by CMR and venography.
We have demonstrated that slow infusion protocol of dimeglumine-gadobenate can be used to assess both CVA and myocardial scar in a single MR examination. Furthermore, an image overlay technique has been used to show the relationship of scar to the CVA. J. Magn. Reson. Imaging 2011;33:87–95. © 2010 Wiley-Liss, Inc.