Diffusion MRI predicts transrectal ultrasound biopsy results in prostate cancer detection
Article first published online: 27 JAN 2011
Copyright © 2011 Wiley-Liss, Inc.
Journal of Magnetic Resonance Imaging
Volume 33, Issue 2, pages 356–363, February 2011
How to Cite
Chen, Y.-J., Pu, Y.-S., Chueh, S.-C., Shun, C.-T., Chu, W.-C. and Tseng, W.-Y. I. (2011), Diffusion MRI predicts transrectal ultrasound biopsy results in prostate cancer detection. J. Magn. Reson. Imaging, 33: 356–363. doi: 10.1002/jmri.22421
- Issue published online: 27 JAN 2011
- Article first published online: 27 JAN 2011
- Manuscript Accepted: 18 OCT 2010
- Manuscript Received: 13 JUL 2010
- National Science Council and the National Health Research Institute, Taiwan. Grant Numbers: NSC 97-2627-B-010-005-3, NHRI 98A1-MEPP11-014
- prostate cancer (PCA);
- diffusion tensor imaging (DTI);
- apparent diffusion coefficient (ADC)
To evaluate the ability of diffusion tensor imaging (DTI) to predict the transrectal ultrasound (TRUS) biopsy outcomes in persons who have no history of previous TRUS biopsy and present with elevated prostate-specific antigen (PSA) levels.
Materials and Methods
Thirty-seven participants underwent DTI, followed by 12-core TRUS-guided needle biopsy within 2 weeks. DTI was performed using endorectal coils on a 1.5 Tesla scanner at 1-mm3 spatial resolution. By comparing with the TRUS biopsy results, the optimum thresholds of the trace apparent diffusion coefficient (tADC) and of the nodular size were investigated. The diagnostic performance of both criteria, the tADC threshold (Criteria A) and the tADC threshold combined with nodular size threshold (Criteria B), were evaluated.
The optimum tADC threshold was 1.0 μm2/ms. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of prostate cancer (PCA) detection for Criteria A were 98%, 89%, 73%, 99%, and 91%, respectively, and were 97%, 98%, 92%, 99% and 98% for Criteria B.
Owing to high negative predictive value, the tADC threshold could be used to exclude subjects with clinically undetectable PCA. Adding the nodular size threshold, the combined threshold could identify the tADC-positive segments that are likely to yield positive biopsy results. J. Magn. Reson. Imaging 2011;33:356–363. © 2011 Wiley-Liss, Inc.