Original Research

Measuring bone erosion and edema in rheumatoid arthritis: A comparison of manual segmentation and RAMRIS methods

  1. Angela R. Crowley MD1,
  2. Jing Dong2,
  3. Alex McHaffie MBChB3,
  4. Andrew W. Clarke MBChB4,
  5. Quentin Reeves MBChB, FRANZCR3,
  6. Megan Williams RCpN1,
  7. Elizabeth Robinson MSc5,
  8. Nicola Dalbeth MD, FRACP1,
  9. Fiona M. McQueen MD, FRACP1,2,*

Article first published online: 27 JAN 2011

DOI: 10.1002/jmri.22425

Issue

Journal of Magnetic Resonance Imaging

Journal of Magnetic Resonance Imaging

Volume 33, Issue 2, pages 364–371, February 2011

Additional Information

How to Cite

Crowley, A. R., Dong, J., McHaffie, A., Clarke, A. W., Reeves, Q., Williams, M., Robinson, E., Dalbeth, N. and McQueen, F. M. (2011), Measuring bone erosion and edema in rheumatoid arthritis: A comparison of manual segmentation and RAMRIS methods. J. Magn. Reson. Imaging, 33: 364–371. doi: 10.1002/jmri.22425

Author Information

  1. 1

    Department of Rheumatology, Greenlane Clinical Centre, Auckland District Health Board, Auckland, New Zealand

  2. 2

    Department of Molecular Medicine and Pathology, Faculty of Medicine and Health Sciences, University of Auckland, Auckland, New Zealand

  3. 3

    Department of Radiology, Musculoskeletal section, Auckland City Hospital, New Zealand

  4. 4

    Department of Radiology, North Shore Hospital, Waitemata District Health Board, Auckland, New Zealand

  5. 5

    Department of Epidemiology and Biostatistics, University of Auckland, New Zealand

*Dept. of Molecular Medicine and Pathology, University of Auckland, 85 Park Rd, Grafton, Auckland, New Zealand

Publication History

  1. Issue published online: 27 JAN 2011
  2. Article first published online: 27 JAN 2011
  3. Manuscript Accepted: 15 OCT 2010
  4. Manuscript Received: 12 FEB 2010

Funded by

  • Auckland Medical Research Foundation
  • Auckland Regional Rheumatology Research Trust
  • University of Auckland (studentship for J.D.)

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (491K)

Keywords:

  • rheumatoid arthritis;
  • magnetic resonance imaging;
  • RAMRIS;
  • segmentation

Abstract

Purpose

To investigate the reliability, feasibility, and validity of a computer-assisted manual segmentation (outlining) technique for measuring magnetic resonance imaging (MRI) bone erosion and edema at the wrist in rheumatoid arthritis (RA).

Materials and Methods

The 3T MRI scans were obtained in 22 RA patients (<2 years). Bone erosion and edema volumes were scored by two readers using outlining and were compared with RAMRIS scores.

Results

Using outlining, intraobserver reliability for erosions and edema was high: intraclass correlation coefficients (ICCs) = 0.994 (0.991, 0.997) and 0.996 (0.994, 0.998), respectively (Reader 1). Interobserver reliability was high for bone erosion (ICC [90% confidence interval, CI] = 0.80 [0.64, 0.92]) and comparable to RAMRIS scoring (ICC 0.78 [0.64, 0.92]), but was only moderate for bone edema (0.46 [0.00, 0.96]), compared with RAMRIS (ICC = 0.84 [0.73, 0.94]). The methods were highly correlated for erosion scores, r = 0.90, 0.82 (Readers 1 and 2) and moderately correlated for edema, r = 0.57, 0.87.

Conclusion

Segmentation (outlining) can be used to measure the volume of MRI bone erosion and edema at the wrist in RA patients. When compared with RAMRIS scoring, outlining had similar reliability for quantifying erosions but reliability was lower for bone edema, possibly reflecting difficulty delineating the borders of affected bone. J. Magn. Reson. Imaging 2011;33:364–371. © 2011 Wiley-Liss, Inc.

View Full Article (HTML) Get PDF (491K)