Quantification of fat infiltration in oculopharyngeal muscular dystrophy: Comparison of three MR imaging methods

Authors

  • Monika Gloor PhD,

    Corresponding author
    1. Division of Radiological Physics, Institute of Radiology, University of Basel Hospital, Basel, Switzerland
    • Division of Radiological Physics, Institute of Radiology, University of Basel Hospital, Petersgraben 4, CH-4031 Basel, Switzerland
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    • Drs. Gloor and Fasler contributed equally to this study.

  • Susanne Fasler MD,

    1. Department of Neuroradiology, Institute of Radiology, University of Basel Hospital, Basel, Switzerland
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    • Drs. Gloor and Fasler contributed equally to this study.

  • Arne Fischmann MD,

    1. Department of Neuroradiology, Institute of Radiology, University of Basel Hospital, Basel, Switzerland
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  • Tanja Haas RT,

    1. Division of Radiological Physics, Institute of Radiology, University of Basel Hospital, Basel, Switzerland
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  • Oliver Bieri PhD,

    1. Division of Radiological Physics, Institute of Radiology, University of Basel Hospital, Basel, Switzerland
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  • Karl Heinimann MD, PhD,

    1. Division of Medical Genetics, University Children's Hospital, Basel, Switzerland
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  • Stephan G. Wetzel MD,

    1. Department of Neuroradiology, Institute of Radiology, University of Basel Hospital, Basel, Switzerland
    2. Department of Neuroradiology, Swiss Neuro Institute, Hirslanden Klinik Zurich, Zurich, Switzerland
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  • Klaus Scheffler PhD,

    1. Division of Radiological Physics, Institute of Radiology, University of Basel Hospital, Basel, Switzerland
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  • Dirk Fischer MD

    1. Department of Neuropaediatrics, University Children's Hospital, Basel, Switzerland
    2. Department of Neurology, University of Basel Hospital, Basel, Switzerland
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Abstract

Purpose

To analyze and compare three quantitative MRI methods to determine the degree of muscle involvement in oculopharyngeal muscular dystrophy (OPMD).

Materials and Methods

Muscle fat content (MFC) was determined based on water–fat quantification using a 2-point Dixon (2PD) method and on a histogram analysis of the free induction decay (FID) signal of a gradient-spoiled steady-state free precession (SSFP) sequence. In addition, transverse relaxation times (T2) of muscle tissue were calculated using a monoexponential decay model.

Results

We observed an increased mean MFC in OPMD patients as compared to healthy controls with the adductor magnus and soleus muscles being the most involved muscles in the thigh and calf, respectively. Furthermore, strong correlations (0.78 < R2 < 0.94) between different quantitative MR methods were observed. Fewer outliers, however, were obtained by the 2PD method and T2 measurements, suggesting these methods being superior to the SSFP-FID method.

Conclusion

Quantitative MR techniques, such as fast multiecho Dixon methods and T2 imaging, can reliably differentiate between healthy and dystrophic muscles in OPMD, even if muscles are only marginally affected. Quantitative methods thus represent a promising tool that may be able to monitor more objectively the individual disease progression and treatment response in future clinical trials in muscular dystrophies. J. Magn. Reson. Imaging 2011;33:203–210. © 2010 Wiley-Liss, Inc.

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