Detailed assessment of the hemodynamic response to psychosocial stress using real-time MRI

Authors

  • Alexander Jones PhD,

    Corresponding author
    1. Centre for Cardiovascular Imaging, UCL Institute of Child Health & Great Ormond Street Hospital for Children, London, United Kingdom
    2. Department of Vascular Physiology, UCL Institute of Child Health, London, United Kingdom
    • Cardiovascular Unit, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, UK
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  • Jennifer A. Steeden MEng,

    1. Centre for Cardiovascular Imaging, UCL Institute of Child Health & Great Ormond Street Hospital for Children, London, United Kingdom
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  • Jens C. Pruessner PhD,

    1. Douglas Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada
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  • John E. Deanfield MB,

    1. Department of Vascular Physiology, UCL Institute of Child Health, London, United Kingdom
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  • Andrew M. Taylor MD,

    1. Centre for Cardiovascular Imaging, UCL Institute of Child Health & Great Ormond Street Hospital for Children, London, United Kingdom
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  • Vivek Muthurangu MD

    1. Centre for Cardiovascular Imaging, UCL Institute of Child Health & Great Ormond Street Hospital for Children, London, United Kingdom
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Abstract

Purpose

To demonstrate that combining the Montreal Imaging Stress Task (MIST) with real-time cardiac magnetic resonance imaging (MRI) allows detailed assessment of the cardiovascular mental stress response.

Materials and Methods

22 healthy volunteers (1:1 M:F, 26–64 years) underwent MRI during rest and the MIST. Real-time spiral phase contrast MR, accelerated with sensitivity encoding (SENSE) was used to assess stroke volume (SV), and radial k-t SENSE was used to assess ventricular volumes. Simultaneous heart rate (HR) and blood pressure (BP) measures allowed calculation of cardiac output (CO), systemic vascular resistance (SVR), and arterial compliance (TAC). Endocrine responses were assessed using salivary cortisol.

Results

In response to stress, BP increased due to increased CO and reduced TAC but not increased SVR, which fell. HR, not SV, determined CO increases. Greater BP responses occurred in men due to greater CO increases and relatively higher SVR. Older participants had greater BP responses due to greater falls in TAC. Greater cortisol response was correlated with greater falls in TAC but resting cortisol and TAC were not related.

Conclusion

This new approach allows detailed, accurate assessment of stress physiology. Preliminary findings suggest stress exposes relationships, not seen at rest, of cardiovascular function with age, sex, and endocrine function. J. Magn. Reson. Imaging 2011;33:448–454. © 2011 Wiley-Liss, Inc.

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