Portal hypertension correlates with splenic stiffness as measured with MR elastography
Article first published online: 23 MAY 2011
Copyright © 2011 Wiley-Liss, Inc.
Journal of Magnetic Resonance Imaging
Volume 34, Issue 1, pages 79–87, July 2011
How to Cite
Nedredal, G. I., Yin, M., McKenzie, T., Lillegard, J., Luebke-Wheeler, J., Talwalkar, J., Ehman, R. and Nyberg, S. L. (2011), Portal hypertension correlates with splenic stiffness as measured with MR elastography. J. Magn. Reson. Imaging, 34: 79–87. doi: 10.1002/jmri.22610
- Issue published online: 22 JUN 2011
- Article first published online: 23 MAY 2011
- Manuscript Accepted: 14 MAR 2011
- Manuscript Received: 30 JUL 2010
- Norwegian Research Council
- NIH. Grant Numbers: RO1-DK56733, EB001981
- magnetic resonance elastography;
- portal hypertension;
- spleen stiffness;
To investigate the correlation between MR elastography (MRE) assessed spleen stiffness and direct portal vein pressure gradient (D-HVPG) measurements in a large animal model of portal hypertension.
Materials and Methods:
Cholestatic liver disease was established in adult canines by common bile duct ligation. A spin echo based echo planar imaging (EPI) MRE sequence was used to acquire three-dimensional/three axis (3D/3-axis) abdominal MRE data at baseline, 4 weeks, and 8 weeks. Liver biopsies, blood samples, and D-HVPG measurements were obtained simultaneously.
Animals developed portal hypertension (D-HVPG: 11.0 ± 5.1 mmHg) with only F1 fibrosis after 4 weeks. F3 fibrosis was confirmed after 8 weeks despite no further rise in portal hypertension (D-HVPG: 11.3 ± 3.2 mmHg). Mean stiffnesses of the spleen increased over two-fold from baseline (1.72 ± 0.33 kPa) to 4 weeks (3.54 ± 0.31 kPa), and stabilized at 8 weeks (3.38 ± 0.06 kPa) in a pattern consistent with changes in portal pressure. A positive correlation was observed between spleen stiffness and D-HVPG (r2 = 0.86; P < 0.01).
These findings indicate a temporal relationship between portal hypertension and the development of liver fibrosis in a large animal model of cholestatic liver disease. The observed direct correlation between spleen stiffness and D-HVPG suggest a noninvasive MRE approach to diagnose and screen for portal hypertension. J. Magn. Reson. Imaging 2011;. © 2011 Wiley-Liss, Inc.