Windowed stochastic proton decoupling for in vivo 13C magnetic resonance spectroscopy with reduced RF power deposition

Authors

  • Yun Xiang MD, PhD,

    1. Molecular Imaging Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland, USA
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  • Jun Shen PhD

    Corresponding author
    1. Molecular Imaging Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland, USA
    • Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bldg. 10, Rm. 2D51A, 9000 Rockville Pike, Bethesda, MD 20892-1527
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Abstract

Purpose:

To propose a strategy for reducing radiofrequency (RF) power deposition by stochastic proton decoupling based on Rayleigh's theorem.

Materials and Methods:

Rayleigh's theorem was used to remove frequency components of stochastic decoupling over the 3.90–6.83 ppm range. [2-13C] or [2,5-13C2]glucose was infused intravenously to anesthetized rats. 13C labeling of brain metabolites was detected in the carboxylic/amide spectral region at 11.7 T using either the original stochastic decoupling method developed by Ernst or the proposed windowed stochastic decoupling method.

Results:

By restricting frequency components of stochastic decoupling to 1.91–3.90 ppm and 6.83–7.60 ppm spectral regions decoupling power deposition was reduced by ≈50%. The proposed windowed stochastic decoupling scheme is experimentally demonstrated for in vivo 13C MRS of rat brain at 11.7 T.

Conclusion:

The large reduction in decoupling power deposition makes it feasible to perform stochastic proton decoupling at very high magnetic fields for human brain 13C MRS studies. J. Magn. Reson. Imaging 2011;. © 2011 Wiley-Liss, Inc.

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