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Reproducibility of MRI-determined proton density fat fraction across two different MR scanner platforms

Authors

  • Geraldine H. Kang BS,

    1. Liver Imaging Group, Department of Radiology, University of California, San Diego Medical Center, University of California at San Diego, MR3T Laboratory, San Diego, California, USA
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  • Irene Cruite MD,

    1. Liver Imaging Group, Department of Radiology, University of California, San Diego Medical Center, University of California at San Diego, MR3T Laboratory, San Diego, California, USA
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  • Masoud Shiehmorteza MD,

    1. Liver Imaging Group, Department of Radiology, University of California, San Diego Medical Center, University of California at San Diego, MR3T Laboratory, San Diego, California, USA
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  • Tanya Wolfson MA,

    1. Computational and Applied Statistics Laboratory, San Diego Supercomputer Center, University of California at San Diego, La Jolla, California, USA
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  • Anthony C. Gamst PhD,

    1. Computational and Applied Statistics Laboratory, San Diego Supercomputer Center, University of California at San Diego, La Jolla, California, USA
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  • Gavin Hamilton PhD,

    1. Liver Imaging Group, Department of Radiology, University of California, San Diego Medical Center, University of California at San Diego, MR3T Laboratory, San Diego, California, USA
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  • Mark Bydder PhD,

    1. Liver Imaging Group, Department of Radiology, University of California, San Diego Medical Center, University of California at San Diego, MR3T Laboratory, San Diego, California, USA
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  • Michael S. Middleton MD, PhD,

    1. Liver Imaging Group, Department of Radiology, University of California, San Diego Medical Center, University of California at San Diego, MR3T Laboratory, San Diego, California, USA
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  • Claude B. Sirlin MD

    Corresponding author
    1. Liver Imaging Group, Department of Radiology, University of California, San Diego Medical Center, University of California at San Diego, MR3T Laboratory, San Diego, California, USA
    • Liver Imaging Group, Department of Radiology, University of California, San Diego Medical Center, University of California at San Diego, MR3T Laboratory, 408 Dickinson St., San Diego, CA 92103-8226
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Abstract

Purpose:

To evaluate magnetic resonance imaging (MRI)-determined proton density fat fraction (PDFF) reproducibility across two MR scanner platforms and, using MR spectroscopy (MRS)-determined PDFF as reference standard, to confirm MRI-determined PDFF estimation accuracy.

Materials and Methods:

This prospective, cross-sectional, crossover, observational pilot study was approved by an Institutional Review Board. Twenty-one subjects gave written informed consent and underwent liver MRI and MRS at both 1.5T (Siemens Symphony scanner) and 3T (GE Signa Excite HD scanner). MRI-determined PDFF was estimated using an axial 2D spoiled gradient-recalled echo sequence with low flip-angle to minimize T1 bias and six echo-times to permit correction of T2* and fat-water signal interference effects. MRS-determined PDFF was estimated using a stimulated-echo acquisition mode sequence with long repetition time to minimize T1 bias and five echo times to permit T2 correction. Interscanner reproducibility of MRI determined PDFF was assessed by correlation analysis; accuracy was assessed separately at each field strength by linear regression analysis using MRS-determined PDFF as reference standard.

Results:

1.5T and 3T MRI-determined PDFF estimates were highly correlated (r = 0.992). MRI-determined PDFF estimates were accurate at both 1.5T (regression slope/intercept = 0.958/-0.48) and 3T (slope/intercept = 1.020/0.925) against the MRS-determined PDFF reference.

Conclusion:

MRI-determined PDFF estimation is reproducible and, using MRS-determined PDFF as reference standard, accurate across two MR scanner platforms at 1.5T and 3T. J. Magn. Reson. Imaging 2011;. © 2011 Wiley-Liss, Inc.

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