MR elastography for noninvasive assessment of hepatic fibrosis: Experience from a tertiary center in asia

Authors

  • Bo Hee Kim BA,

    1. Department of Radiology, Seoul National University College of Medicine, Seoul, Korea
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  • Jeong Min Lee MD,

    Corresponding author
    1. Department of Radiology, Seoul National University College of Medicine, Seoul, Korea
    2. Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul, Korea
    • Department of Radiology, Seoul National University Hospital, 101 Daehangno, Jongno-gu, Seoul, 110-744, Korea
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  • Ye Ji Lee BA,

    1. Department of Radiology, Seoul National University College of Medicine, Seoul, Korea
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  • Kyoung Bun Lee MD,

    1. Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
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  • Kyung-Suk Suh MD,

    1. Department of Surgery, Seoul National University College of Medicine, Seoul, Korea
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  • Joon Koo Han MD,

    1. Department of Radiology, Seoul National University College of Medicine, Seoul, Korea
    2. Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul, Korea
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  • Byung Ihn Choi MD

    1. Department of Radiology, Seoul National University College of Medicine, Seoul, Korea
    2. Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul, Korea
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Abstract

Purpose:

To determine the sensitivity and specificity of MR elastography (MRE) in the staging of hepatic fibrosis (HF) using histopathology as the reference standard in an Asian population.

Materials and Methods:

MRE was performed on 55 patients with chronic liver diseases or biliary diseases and on 5 living related liver donors (48 men and 12 women; mean age, 55.7 years). MRE was performed with modified, phase-contrast, gradient-echo sequences, and the mean stiffness values were measured on the elastograms in kilopascals(kPa). Receiver operating characteristic curve analysis was performed to determine the cutoff value and accuracy of MRE for staging HF. Histopathologic staging of HF according to the METAVIR scoring system served as the reference.

Results:

Liver stiffness increased systematically along with the fibrosis stage. With a shear stiffness cutoff value of 3.05 kPa, the predicted sensitivity and specificity for differentiating significant liver fibrosis (≥ F2) from mild fibrosis (F1) were 89.7% and 87.1%, respectively. In addition, MRE was able to discriminate between patients with severe fibrosis (F3) and those with liver cirrhosis (sensitivity, 100%; specificity, 92.2%), with a shear stiffness cutoff value of 5.32 kPa.

Conclusion:

MRE could be a promising, noninvasive technique with excellent diagnostic accuracy for detecting significant HF and liver cirrhosis. J. Magn. Reson. Imaging 2011. © 2011 Wiley Periodicals, Inc.

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