Get access

Does vertebral bone marrow fat content correlate with abdominal adipose tissue, lumbar spine bone mineral density, and blood biomarkers in women with type 2 diabetes mellitus?

Authors

  • Thomas Baum MD,

    Corresponding author
    1. Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA
    • Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry Street, Suite 350, San Francisco, CA 94107
    Search for more papers by this author
  • Samuel P. Yap BA,

    1. Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA
    Search for more papers by this author
    • Dimitrios C. Karampinos PhD,

      1. Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA
      Search for more papers by this author
    • Lorenzo Nardo MD,

      1. Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA
      Search for more papers by this author
    • Daniel Kuo BSc,

      1. Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA
      Search for more papers by this author
    • Andrew J. Burghardt BSc,

      1. Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA
      Search for more papers by this author
    • Umesh B. Masharani MD,

      1. The Diabetes Center, University of California San Francisco, San Francisco, California, USA
      Search for more papers by this author
    • Ann V. Schwartz PhD,

      1. Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA
      Search for more papers by this author
    • Xiaojuan Li PhD,

      1. Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA
      Search for more papers by this author
    • Thomas M. Link MD

      1. Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA
      Search for more papers by this author

    • Drs. Baum and Yap contributed equally to this work.

    Abstract

    Purpose:

    To compare vertebral bone marrow fat content quantified with proton MR spectroscopy (1H-MRS) with the volume of abdominal adipose tissue, lumbar spine volumetric bone mineral density (vBMD), and blood biomarkers in postmenopausal women with and without type 2 diabetes mellitus (T2DM).

    Materials and Methods:

    Thirteen postmenopausal women with T2DM and 13 age- and body mass index-matched healthy controls were included in this study. All subjects underwent 1H-MRS of L1–L3 to quantify vertebral bone marrow fat content (FC) and unsaturated lipid fraction (ULF). Quantitative computed tomography (QCT) was performed to assess vBMD of L1–L3. The volumes of abdominal subcutaneous/visceral/total adipose tissue were determined from the QCT images and adjusted for abdominal body volume (SATadj/VATadj/TATadj). Fasting blood tests included plasma glucose and HbA1c.

    Results:

    Mean FC showed an inverse correlation with vBMD (r = −0.452; P < 0.05) in the whole study population. While mean FC was similar in the diabetic women and healthy controls (69.3 ± 7.5% versus 67.5 ± 6.1%; P > 0.05), mean ULF was significantly lower in the diabetic group (6.7 ± 1.0% versus 7.9 ± 1.6%; P < 0.05). SATadj and TATadj correlated significantly with mean FC in the whole study population (r = 0.538 and r = 0.466; P < 0.05). In contrast to the control group, significant correlations of mean FC with VATadj and HbA1c were observed in the diabetic group (r = 0.642 and r = 0.825; P < 0.05).

    Conclusion:

    This study demonstrated that vertebral bone marrow fat content correlates significantly with SATadj, TATadj, and lumbar spine vBMD in postmenopausal women with and without T2DM, but with VATadj and HbA1c only in women with T2DM. J. Magn. Reson. Imaging 2012;35:117-124. © 2011 Wiley Periodicals, Inc.

    Get access to the full text of this article

    Ancillary