Cross-validation of MR elastography and ultrasound transient elastography in liver stiffness measurement: discrepancy in the results of cirrhotic liver

Authors


  • There was no financial support for this work.

Abstract

Purpose:

To evaluate individual differences in liver stiffness measurement using both MR elastography (MRE) and ultrasound transient elastography (UTE) in patients with chronic liver disease.

Materials and Methods:

This study included 80 patients with chronic liver disease who underwent both UTE and MRE. MRE and UTE were performed using a pneumatic driver (60 Hz) and an ultrasound probe with a vibrator (50 Hz), respectively. Liver stiffness data measured using the two techniques (μUTE and μMRE) were compared with respect to shear modulus. The patients were subdivided into four quartiles on the basis of average of the μUTE and μMRE values for each patient.

Results:

The analysis of the 4 quartile groups revealed that μUTE was significantly higher than μMRE in the two most stiff liver groups: μUTE versus μMRE, 7.5 (1.2) versus 6.0 (0.72) kPa for the group with [μUTE + μMRE]/2 of 5.6–8.0 kPa; 15.1(4.2) versus 6.7 (1.4) kPa for the group with >8.0 kPa. However, in the least stiff liver group (i.e., the group with [μUTE + μMRE]/2 < 3.2 kPa), μUTE was significantly lower than μMRE.

Conclusion:

The shear modulus measured by UTE and MRE are not equivalent, especially in patients with stiff livers. J. Magn. Reson. Imaging 2012;35:607-610. © 2011 Wiley Periodicals, Inc.

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