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Original Research

Perfusion parameters analysis of the vertebral bone marrow in patients with Ph1− chronic myeloproliferative neoplasms (PhnegMPN): A dynamic contrast-enhanced MRI (DCE-MRI) study

  1. Nikos Courcoutsakis MD, D(Med)Sci1,*,
  2. Athina Spanoudaki MD1,
  3. Thomas G. Maris PhD2,
  4. Emmanuel Astrinakis MD1,
  5. Emmanuel Spanoudakis MD3,
  6. Constantinos Tsatalas MD, PhD3,
  7. Panos Prassopoulos MD, PhD1

Article first published online: 8 NOV 2011

DOI: 10.1002/jmri.22870

Issue

Journal of Magnetic Resonance Imaging

Journal of Magnetic Resonance Imaging

Volume 35, Issue 3, pages 696–702, March 2012

Additional Information

How to Cite

Courcoutsakis, N., Spanoudaki, A., Maris, T. G., Astrinakis, E., Spanoudakis, E., Tsatalas, C. and Prassopoulos, P. (2012), Perfusion parameters analysis of the vertebral bone marrow in patients with Ph1− chronic myeloproliferative neoplasms (PhnegMPN): A dynamic contrast-enhanced MRI (DCE-MRI) study. J. Magn. Reson. Imaging, 35: 696–702. doi: 10.1002/jmri.22870

Author Information

  1. 1

    Department of Radiology and Medical Imaging, Medical School, Democritus University of Thrace, Greece

  2. 2

    Department of Medical Physics, Medical School, University of Crete, Greece

  3. 3

    Department of Hematology, Medical School, Democritus University of Thrace, Greece

*Department of Radiology and Medical Imaging, University Hospital of Alexandroupolis, 68100 Alexandroupolis, Greece

Publication History

  1. Issue published online: 14 FEB 2012
  2. Article first published online: 8 NOV 2011
  3. Manuscript Accepted: 4 OCT 2011
  4. Manuscript Received: 28 MAY 2011

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Keywords:

  • perfusion;
  • dynamic contrast enhanced MRI (DCE-MRI);
  • myelofibrosis;
  • essential thrombocythemia;
  • polycythemia vera

Abstract

Purpose:

To evaluate perfusion parameters of the vertebral bone marrow in patients with Philadelphia negative chronic myeloproliferative neoplasms (PhnegMPN) using dynamic contrast-enhanced MRI (DCE-MRI).

Materials and Methods:

The study enrolled 24 patients with PhnegMPN: 12 patients with myelofibrosis (Group A), 6 with essential thrombocythemia (ET), and 6 with polycythemia vera (PV) (Group B) who underwent DCE-MRI of the lumbosacral spine. Twelve normal individuals served as control group (Group C). Wash-in (WIN), wash-out (WOUT), maximum contrast-enhancement (CEmath image), time-to-peak (TTPK), time-to-maximum slope (TMSP), and the WIN/TMSP ratio (WTSP) were calculated.

Results:

WIN, CEmax, and WTSP parameters were higher in Group A than in Group C (P < 0.05). These parameters were significant (P < 0.0001) in discriminating patients with myelofibrosis from normal individuals with sensitivities 74.14%, 87.93%, 74.14%, and specificities 91.07%, 83.93%, 91.07%, respectively. WIN, WOUT, CEmax, and WTSP parameters were higher in Group A than in Group B (P < 0.05). Group B exhibited no differences in perfusion parameters as compared with Group C with the exception of WOUT.

Conclusion:

Patients with myelofibrosis exhibited increased perfusion parameters in vertebral bone marrow, which could be consisted with increased vascularity, probably related to neoangiogenesis as opposed to ET or PV patients showing no increased perfusion. DCE-MRI may be of value in discriminating subgroups of PhnegMPN patients and in indicating those progressing to myelofibrosis. J. Magn. Reson. Imaging 2012;35:696-702. © 2011 Wiley Periodicals, Inc.

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