Perfusion parameters analysis of the vertebral bone marrow in patients with Ph1− chronic myeloproliferative neoplasms (PhnegMPN): A dynamic contrast-enhanced MRI (DCE-MRI) study
Article first published online: 8 NOV 2011
Copyright © 2011 Wiley-Liss, Inc.
Journal of Magnetic Resonance Imaging
Volume 35, Issue 3, pages 696–702, March 2012
How to Cite
Courcoutsakis, N., Spanoudaki, A., Maris, T. G., Astrinakis, E., Spanoudakis, E., Tsatalas, C. and Prassopoulos, P. (2012), Perfusion parameters analysis of the vertebral bone marrow in patients with Ph1− chronic myeloproliferative neoplasms (PhnegMPN): A dynamic contrast-enhanced MRI (DCE-MRI) study. J. Magn. Reson. Imaging, 35: 696–702. doi: 10.1002/jmri.22870
- Issue published online: 14 FEB 2012
- Article first published online: 8 NOV 2011
- Manuscript Accepted: 4 OCT 2011
- Manuscript Received: 28 MAY 2011
- dynamic contrast enhanced MRI (DCE-MRI);
- essential thrombocythemia;
- polycythemia vera
To evaluate perfusion parameters of the vertebral bone marrow in patients with Philadelphia negative chronic myeloproliferative neoplasms (PhnegMPN) using dynamic contrast-enhanced MRI (DCE-MRI).
Materials and Methods:
The study enrolled 24 patients with PhnegMPN: 12 patients with myelofibrosis (Group A), 6 with essential thrombocythemia (ET), and 6 with polycythemia vera (PV) (Group B) who underwent DCE-MRI of the lumbosacral spine. Twelve normal individuals served as control group (Group C). Wash-in (WIN), wash-out (WOUT), maximum contrast-enhancement (CE), time-to-peak (TTPK), time-to-maximum slope (TMSP), and the WIN/TMSP ratio (WTSP) were calculated.
WIN, CEmax, and WTSP parameters were higher in Group A than in Group C (P < 0.05). These parameters were significant (P < 0.0001) in discriminating patients with myelofibrosis from normal individuals with sensitivities 74.14%, 87.93%, 74.14%, and specificities 91.07%, 83.93%, 91.07%, respectively. WIN, WOUT, CEmax, and WTSP parameters were higher in Group A than in Group B (P < 0.05). Group B exhibited no differences in perfusion parameters as compared with Group C with the exception of WOUT.
Patients with myelofibrosis exhibited increased perfusion parameters in vertebral bone marrow, which could be consisted with increased vascularity, probably related to neoangiogenesis as opposed to ET or PV patients showing no increased perfusion. DCE-MRI may be of value in discriminating subgroups of PhnegMPN patients and in indicating those progressing to myelofibrosis. J. Magn. Reson. Imaging 2012;35:696-702. © 2011 Wiley Periodicals, Inc.