Original Research

Cine cerebrospinal fluid imaging in multiple sclerosis

  1. Christopher Magnano MS1,
  2. Claudiu Schirda PhD1,
  3. Bianca Weinstock-Guttman MD2,
  4. David S. Wack PhD1,
  5. Eric Lindzen MD PhD2,
  6. David Hojnacki MD2,
  7. Niels Bergsland BS1,
  8. Cheryl Kennedy LMSW, MPH1,
  9. Pavel Belov XX1,
  10. Michael G. Dwyer MS1,
  11. Guy U. Poloni PhD1,
  12. Clive B. Beggs PhD3,
  13. Robert Zivadinov MD, PhD1,2,*

Article first published online: 25 JUN 2012

DOI: 10.1002/jmri.23730

Issue

Journal of Magnetic Resonance Imaging

Journal of Magnetic Resonance Imaging

Volume 36, Issue 4, pages 825–834, October 2012

Additional Information

How to Cite

Magnano, C., Schirda, C., Weinstock-Guttman, B., Wack, D. S., Lindzen, E., Hojnacki, D., Bergsland, N., Kennedy, C., Belov, P., Dwyer, M. G., Poloni, G. U., Beggs, C. B. and Zivadinov, R. (2012), Cine cerebrospinal fluid imaging in multiple sclerosis. J. Magn. Reson. Imaging, 36: 825–834. doi: 10.1002/jmri.23730

Author Information

  1. 1

    Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, New York, USA

  2. 2

    Jacobs Neurological Institute, Department of Neurology, University at Buffalo, State University of New York, Buffalo, New York, USA

  3. 3

    Centre for Infection Control and Biophysics, University of Bradford, Bradford, UK

*Department of Neurology, School of Medicine and Biomedical Sciences, Buffalo Neuroimaging Analysis Center, 100 High St., Buffalo, NY 14203

Publication History

  1. Issue published online: 14 SEP 2012
  2. Article first published online: 25 JUN 2012
  3. Manuscript Accepted: 10 MAY 2012
  4. Manuscript Received: 16 JUN 2011

Funded by

  • internal resources of the Buffalo Neuroimaging Analysis Center and Baird MS Center, Jacobs Neurological Institute, University of Buffalo

SEARCH

SEARCH BY CITATION

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Keywords:

  • multiple sclerosis;
  • MRI;
  • cerebrospinal fluid;
  • phase contrast imaging;
  • aqueduct of Sylvius

Abstract

Purpose:

To investigate cerebrospinal fluid (CSF) dynamics in the aqueduct of Sylvius in multiple sclerosis (MS) patients and healthy controls (HC) using cine phase contrast imaging.

Materials and Methods:

In all, 67 MS patients (48 relapsing-remitting [RR] and 19 secondary-progressive [SP]), nine patients with clinically isolated syndrome (CIS), and 35 age- and sex-matched HC were examined. CSF flow and velocity measures were quantified using a semiautomated method and compared with clinical and magnetic resonance imaging (MRI) disease outcomes.

Results:

Significantly decreased CSF net flow was detected in MS patients compared to HC (−3.7 vs. −7.1 μL/beat, P = 0.005). There was a trend for increased net positive flow between SP, RR, and CIS patients. Altered CSF flow and velocity measures were associated with more severe T1 and T2 lesion volumes, lateral and fourth ventricular volumes, and third ventricular width in MS and CIS patients (P < 0.01 for all). In CIS patients, conversion to clinically definite MS in the following year was related to decreased CSF net flow (P = 0.007). There was a trend between increased annual relapse rate and altered CSF flow/velocity measures in RRMS patients (P < 0.05).

Conclusion:

CSF flow dynamics are altered in MS patients. More severe clinical and MRI outcomes in RRMS and CIS patients relate to altered CSF flow and velocity measures. J. Magn. Reson. Imaging 2012;36:825–834. © 2012 Wiley Periodicals, Inc.

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