Cine cerebrospinal fluid imaging in multiple sclerosis
Article first published online: 25 JUN 2012
Copyright © 2012 Wiley Periodicals, Inc.
Journal of Magnetic Resonance Imaging
Volume 36, Issue 4, pages 825–834, October 2012
How to Cite
Magnano, C., Schirda, C., Weinstock-Guttman, B., Wack, D. S., Lindzen, E., Hojnacki, D., Bergsland, N., Kennedy, C., Belov, P., Dwyer, M. G., Poloni, G. U., Beggs, C. B. and Zivadinov, R. (2012), Cine cerebrospinal fluid imaging in multiple sclerosis. J. Magn. Reson. Imaging, 36: 825–834. doi: 10.1002/jmri.23730
- Issue published online: 14 SEP 2012
- Article first published online: 25 JUN 2012
- Manuscript Accepted: 10 MAY 2012
- Manuscript Received: 16 JUN 2011
- internal resources of the Buffalo Neuroimaging Analysis Center and Baird MS Center, Jacobs Neurological Institute, University of Buffalo
- multiple sclerosis;
- cerebrospinal fluid;
- phase contrast imaging;
- aqueduct of Sylvius
To investigate cerebrospinal fluid (CSF) dynamics in the aqueduct of Sylvius in multiple sclerosis (MS) patients and healthy controls (HC) using cine phase contrast imaging.
Materials and Methods:
In all, 67 MS patients (48 relapsing-remitting [RR] and 19 secondary-progressive [SP]), nine patients with clinically isolated syndrome (CIS), and 35 age- and sex-matched HC were examined. CSF flow and velocity measures were quantified using a semiautomated method and compared with clinical and magnetic resonance imaging (MRI) disease outcomes.
Significantly decreased CSF net flow was detected in MS patients compared to HC (−3.7 vs. −7.1 μL/beat, P = 0.005). There was a trend for increased net positive flow between SP, RR, and CIS patients. Altered CSF flow and velocity measures were associated with more severe T1 and T2 lesion volumes, lateral and fourth ventricular volumes, and third ventricular width in MS and CIS patients (P < 0.01 for all). In CIS patients, conversion to clinically definite MS in the following year was related to decreased CSF net flow (P = 0.007). There was a trend between increased annual relapse rate and altered CSF flow/velocity measures in RRMS patients (P < 0.05).
CSF flow dynamics are altered in MS patients. More severe clinical and MRI outcomes in RRMS and CIS patients relate to altered CSF flow and velocity measures. J. Magn. Reson. Imaging 2012;36:825–834. © 2012 Wiley Periodicals, Inc.