Improved fat water separation with water selective inversion pulse for inversion recovery imaging in cardiac MRI
Article first published online: 23 AUG 2012
Copyright © 2012 Wiley Periodicals, Inc.
Journal of Magnetic Resonance Imaging
Volume 37, Issue 2, pages 484–490, February 2013
How to Cite
Havla, L., Basha, T., Rayatzadeh, H., Shaw, J. L., Manning, W. J., Reeder, S. B., Kozerke, S. and Nezafat, R. (2013), Improved fat water separation with water selective inversion pulse for inversion recovery imaging in cardiac MRI. J. Magn. Reson. Imaging, 37: 484–490. doi: 10.1002/jmri.23779
- Issue published online: 24 JAN 2013
- Article first published online: 23 AUG 2012
- Manuscript Accepted: 20 JUL 2012
- Manuscript Received: 2 JAN 2012
- National Institutes of Health (NIH). Grant Number: R01EB008743-01A2
- Bayer Science & Education Foundation (fellowship)
- water-fat separation;
- cardiac MRI;
- coronary MRI;
- late gadolinium enhancement
To develop an improved chemical shift-based water-fat separation sequence using a water-selective inversion pulse for inversion recovery 3D contrast-enhanced cardiac magnetic resonance imaging (MRI).
Materials and Methods:
In inversion recovery sequences the fat signal is substantially reduced due to the application of a nonselective inversion pulse. Therefore, for simultaneous visualization of water, fat, and myocardial enhancement in inversion recovery-based sequences such as late gadolinium enhancement imaging, two separate scans are used. To overcome this, the nonselective inversion pulse is replaced with a water-selective inversion pulse. Imaging was performed in phantoms, nine healthy subjects, and nine patients with suspected arrhythmogenic right ventricular cardiomyopathy plus one patient for tumor/mass imaging. In patients, images with conventional turbo-spin echo (TSE) with and without fat saturation were acquired prior to contrast injection for fat assessment. Subjective image scores (1 = poor, 4 = excellent) were used for image assessment.
Phantom experiments showed a fat signal-to-noise ratio (SNR) increase between 1.7 to 5.9 times for inversion times of 150 and 300 msec, respectively. The water-selective inversion pulse retains the fat signal in contrast-enhanced cardiac MR, allowing improved visualization of fat in the water-fat separated images of healthy subjects with a score of 3.7 ± 0.6. Patient images acquired with the proposed sequence were scored higher when compared with a TSE sequence (3.5 ± 0.7 vs. 2.2 ± 0.5, P < 0.05).
The water-selective inversion pulse retains the fat signal in inversion recovery-based contrast-enhanced cardiac MR, allowing simultaneous visualization of water and fat. J. Magn. Reson. Imaging 2013;37:484–490. © 2012 Wiley Periodicals, Inc.