Get access

Improved fat water separation with water selective inversion pulse for inversion recovery imaging in cardiac MRI

Authors

  • Lukas Havla MS,

    1. Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    2. Institute for Biomedical Engineering, University and ETH Zurich, Switzerland
    Search for more papers by this author
  • Tamer Basha PhD,

    1. Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Search for more papers by this author
  • Hussein Rayatzadeh MD,

    1. Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Search for more papers by this author
  • Jaime L. Shaw BS,

    1. Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Search for more papers by this author
  • Warren J. Manning MD,

    1. Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    2. Department of Radiology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Search for more papers by this author
  • Scott B. Reeder MD, PhD,

    1. Department of Radiology, University of Wisconsin, Madison, Wisconsin, USA
    Search for more papers by this author
  • Sebastian Kozerke PhD,

    1. Institute for Biomedical Engineering, University and ETH Zurich, Switzerland
    Search for more papers by this author
  • Reza Nezafat PhD

    Corresponding author
    1. Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    • Beth Israel Deaconess Medical Center, 330 Brookline Ave., Boston, MA, 02215
    Search for more papers by this author

Abstract

Purpose:

To develop an improved chemical shift-based water-fat separation sequence using a water-selective inversion pulse for inversion recovery 3D contrast-enhanced cardiac magnetic resonance imaging (MRI).

Materials and Methods:

In inversion recovery sequences the fat signal is substantially reduced due to the application of a nonselective inversion pulse. Therefore, for simultaneous visualization of water, fat, and myocardial enhancement in inversion recovery-based sequences such as late gadolinium enhancement imaging, two separate scans are used. To overcome this, the nonselective inversion pulse is replaced with a water-selective inversion pulse. Imaging was performed in phantoms, nine healthy subjects, and nine patients with suspected arrhythmogenic right ventricular cardiomyopathy plus one patient for tumor/mass imaging. In patients, images with conventional turbo-spin echo (TSE) with and without fat saturation were acquired prior to contrast injection for fat assessment. Subjective image scores (1 = poor, 4 = excellent) were used for image assessment.

Results:

Phantom experiments showed a fat signal-to-noise ratio (SNR) increase between 1.7 to 5.9 times for inversion times of 150 and 300 msec, respectively. The water-selective inversion pulse retains the fat signal in contrast-enhanced cardiac MR, allowing improved visualization of fat in the water-fat separated images of healthy subjects with a score of 3.7 ± 0.6. Patient images acquired with the proposed sequence were scored higher when compared with a TSE sequence (3.5 ± 0.7 vs. 2.2 ± 0.5, P < 0.05).

Conclusion:

The water-selective inversion pulse retains the fat signal in inversion recovery-based contrast-enhanced cardiac MR, allowing simultaneous visualization of water and fat. J. Magn. Reson. Imaging 2013;37:484–490. © 2012 Wiley Periodicals, Inc.

Get access to the full text of this article

Ancillary