1H-MR spectroscopy and diffusion tensor imaging of normal-appearing temporal white matter in patients with nasopharyngeal carcinoma after irradiation: Initial experience
Article first published online: 12 SEP 2012
Copyright © 2012 Wiley Periodicals, Inc.
Journal of Magnetic Resonance Imaging
Volume 37, Issue 1, pages 101–108, January 2013
How to Cite
Xiong, W. F., Qiu, S. J., Wang, H. Z. and Lv, X. F. (2013), 1H-MR spectroscopy and diffusion tensor imaging of normal-appearing temporal white matter in patients with nasopharyngeal carcinoma after irradiation: Initial experience. J. Magn. Reson. Imaging, 37: 101–108. doi: 10.1002/jmri.23788
- Issue published online: 17 DEC 2012
- Article first published online: 12 SEP 2012
- Manuscript Accepted: 25 JUL 2012
- Manuscript Received: 17 NOV 2011
- The Natural Science Foundation of China. Grant Number: 30770613
- The Natural Science Foundation of Guangdong Province. Grant Numbers: 7005166, 10151051501000087
- The Projiect of Guangdong provincial Science and Technology Plan. Grant Numbers: 2008B030301147, 2011B060200002
- The Projiect of Guangzhou municipal Science and Technology Plan. Grant Number: 11A52120825
- nasopharyngeal carcinoma;
- nuclear MR spectroscopy;
- diffusion-tensor imaging
To detect radiation-induced changes of temporal lobe normal-appearing white mater (NAWM) following radiation therapy (RT) for nasopharyngeal carcinoma (NPC).
Materials and Methods:
Seventy-five H1-MR spectroscopy and diffusion-tensor imaging (DTI) examinations were performed in 55 patients before and after receiving fractionated radiation therapy (total dose; 66–75GY). We divided the dataset into six groups, a pre-RT control group and five other groups based on time after completion of RT. N-acetylaspartic acid (NAA)/choline (Cho), NAA/creatine (Cr), Cho/Cr, mean diffusibility (MD), functional anisotropy (FA), radial diffusibility (λ⟂), and axial diffusibility (λ||) were calculated.
NAA/Cho and NAA/Cr decreased and λ⟂ increased significantly within 1 year after RT compared with pre-RT. After 1 year, NAA/Cho, NAA/Cr, and λ⟂ were not significantly different from pre-RT. In all post-RT groups, FA decreased significantly. λ|| decreased within 9 months after RT compared with pre-RT, but was not significantly different from pre-RT more than 9 months after RT.
DTI and H1-MR spectroscopy can be used to detect early radiation-induced changes of temporal lobe NAWM following radiation therapy for NPC. Metabolic alterations and water diffusion characteristics of temporal lobe NAWM in patients with NPC after RT were dynamic and transient. J. Magn. Reson. Imaging 2013;37:101–108. © 2012 Wiley Periodicals, Inc.