Four-dimensional velocity-encoded magnetic resonance imaging improves blood flow quantification in patients with complex accelerated flow
Article first published online: 13 SEP 2012
Copyright © 2012 Wiley Periodicals, Inc.
Journal of Magnetic Resonance Imaging
Volume 37, Issue 1, pages 208–216, January 2013
How to Cite
Nordmeyer, S., Riesenkampff, E., Messroghli, D., Kropf, S., Nordmeyer, J., Berger, F. and Kuehne, T. (2013), Four-dimensional velocity-encoded magnetic resonance imaging improves blood flow quantification in patients with complex accelerated flow. J. Magn. Reson. Imaging, 37: 208–216. doi: 10.1002/jmri.23793
- Issue published online: 17 DEC 2012
- Article first published online: 13 SEP 2012
- Manuscript Accepted: 27 JUL 2012
- Manuscript Received: 15 NOV 2011
- Federal Ministry of Education and Research. Grant Number: 01EV0704
- 4D VEC MRI;
- blood flow quantification;
- semilunar valve stenosis
To evaluate the use of four-dimensional (4D) velocity-encoded magnetic resonance imaging (VEC MRI) for blood flow quantification in patients with semilunar valve stenosis and complex accelerated flow.
Materials and Methods:
Peak velocities (Vmax) and stroke volumes (SV) were quantified by 2D and 4D VEC MRI in volunteers (n = 7) and patients with semilunar valve stenosis (n = 18). Measurements were performed above the aortic and pulmonary valve with both techniques and, additionally, at multiple predefined planes in the ascending aorta and in the pulmonary trunk within the 4D dataset. In patients, 4D VEC MRI streamline analysis identified flow patterns and regions of highest flow velocity (4Dmax-targeted) for further measurements and Vmax was also measured by Doppler-echocardiography.
In patients, 4D VEC MRI showed higher Vmax than 2D VEC MRI (2.7 ± 0.6 m/s vs. 2.4 ± 0.5 m/s, P < 0.03) and was more comparable to Doppler-echocardiography (2.8 ± 0.7 m/s). 4Dmax-targeted revealed highest Vmax values (3.1 ± 0.6 m/s). SV measurements showed significant differences between different anatomical levels in the ascending aorta in patients with complex accelerated flow, whereas differences in volunteers with laminar flow patterns were negligible (P = 0.004).
4D VEC MRI improves MRI-derived blood flow quantification in patients with semilunar valve stenosis and complex accelerated flow. J. Magn. Reson. Imaging 2013;37:208–216. © 2012 Wiley Periodicals, Inc.