Four-dimensional velocity-encoded magnetic resonance imaging improves blood flow quantification in patients with complex accelerated flow

Authors

  • Sarah Nordmeyer MD,

    Corresponding author
    1. Deutsches Herzzentrum Berlin, Unit of Cardiovascular Imaging, Department of Congenital Heart Disease and Pediatric Cardiology, Berlin, Germany
    • Deutsches Herzzentrum Berlin, Unit of Cardiovascular Imaging, Department of Congenital Heart Disease and Pediatric Cardiology, Augustenburger Platz 1, 13353 Berlin, Germany
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  • Eugénie Riesenkampff MD,

    1. Deutsches Herzzentrum Berlin, Unit of Cardiovascular Imaging, Department of Congenital Heart Disease and Pediatric Cardiology, Berlin, Germany
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  • Daniel Messroghli MD,

    1. Deutsches Herzzentrum Berlin, Unit of Cardiovascular Imaging, Department of Congenital Heart Disease and Pediatric Cardiology, Berlin, Germany
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  • Siegfried Kropf PhD,

    1. University of Magdeburg, Institute for Biometry and Medical Informatics, Magdeburg, Germany
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  • Johannes Nordmeyer MD,

    1. Deutsches Herzzentrum Berlin, Department of Congenital Heart Disease and Pediatric Cardiology, Berlin, Germany
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  • Felix Berger MD,

    1. Deutsches Herzzentrum Berlin, Department of Congenital Heart Disease and Pediatric Cardiology, Berlin, Germany
    2. Charité Universitaetsmedizin Berlin, Department of Pediatric Cardiology, Berlin, Germany
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  • Titus Kuehne MD

    1. Deutsches Herzzentrum Berlin, Unit of Cardiovascular Imaging, Department of Congenital Heart Disease and Pediatric Cardiology, Berlin, Germany
    2. Charité Universitaetsmedizin Berlin, Department of Pediatric Cardiology, Berlin, Germany
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Abstract

Purpose:

To evaluate the use of four-dimensional (4D) velocity-encoded magnetic resonance imaging (VEC MRI) for blood flow quantification in patients with semilunar valve stenosis and complex accelerated flow.

Materials and Methods:

Peak velocities (Vmax) and stroke volumes (SV) were quantified by 2D and 4D VEC MRI in volunteers (n = 7) and patients with semilunar valve stenosis (n = 18). Measurements were performed above the aortic and pulmonary valve with both techniques and, additionally, at multiple predefined planes in the ascending aorta and in the pulmonary trunk within the 4D dataset. In patients, 4D VEC MRI streamline analysis identified flow patterns and regions of highest flow velocity (4Dmax-targeted) for further measurements and Vmax was also measured by Doppler-echocardiography.

Results:

In patients, 4D VEC MRI showed higher Vmax than 2D VEC MRI (2.7 ± 0.6 m/s vs. 2.4 ± 0.5 m/s, P < 0.03) and was more comparable to Doppler-echocardiography (2.8 ± 0.7 m/s). 4Dmax-targeted revealed highest Vmax values (3.1 ± 0.6 m/s). SV measurements showed significant differences between different anatomical levels in the ascending aorta in patients with complex accelerated flow, whereas differences in volunteers with laminar flow patterns were negligible (P = 0.004).

Conclusion:

4D VEC MRI improves MRI-derived blood flow quantification in patients with semilunar valve stenosis and complex accelerated flow. J. Magn. Reson. Imaging 2013;37:208–216. © 2012 Wiley Periodicals, Inc.

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