Modified cine inversion recovery pulse sequence for the quantification of myocardial T1 and gadolinium partition coefficient
Article first published online: 20 SEP 2012
Copyright © 2012 Wiley Periodicals, Inc.
Journal of Magnetic Resonance Imaging
Volume 37, Issue 1, pages 109–118, January 2013
How to Cite
Milanesi, M., Barison, A., Positano, V., Masci, P. G., De Marchi, D., Marinelli, L., Hardy, C. J., Foo, T. K., Landini, L. and Lombardi, M. (2013), Modified cine inversion recovery pulse sequence for the quantification of myocardial T1 and gadolinium partition coefficient. J. Magn. Reson. Imaging, 37: 109–118. doi: 10.1002/jmri.23807
- Issue published online: 17 DEC 2012
- Article first published online: 20 SEP 2012
- Manuscript Accepted: 7 AUG 2012
- Manuscript Received: 31 MAY 2011
- T1 quantification;
- gadolinium partition coefficient;
- cine inversion recovery;
To optimize and validate a modified cine inversion recovery sequence (MCine-IR) for myocardial T1 quantification and gadolinium partition coefficient (λGd) estimation at 1.5 T.
Materials and Methods:
The original version of the cine inversion recovery sequence was modified to allow fully transverse magnetization recovery between two successive inversion pulses. Sixty heart phases were acquired from a number of heart cycles determined on a patient heart rate basis. Phantom studies were carried out to find the optimal effective TR for myocardial and blood pool T1 quantifications in pre- and postcontrast studies. Four patients with myocardial infarct (MI) and 22 dilated cardiomyopathy (DCM) were investigated, as well as 11 healthy subjects used as controls.
Effective TR was identified to be 5000 msec and 2000 msec, respectively, for pre- and postcontrast studies. A longer precontrast (948 ± 102 msec) and shorter postcontrast (348 ± 27 msec) T1 in ischemic patients relative to DCM (815 ± 98 msec, P = 0.03 and 409 ± 42 msec, P = 0.001) were noted in delayed enhancement (DE) areas. In MI patients λGd resulted higher than in DCM in DE areas (609 ± 167 vs. 422 ± 52, P = 0.01) but lower in segments not exhibiting DE (355 ± 100 vs. 398 ± 54, P = 0.02).
It was feasible to measure T1 and λGd with MCine-IR and the results were in good agreement with the literature. J. Magn. Reson. Imaging 2013;37:109–118. © 2012 Wiley Periodicals, Inc.