Comparison of MRS and DWI in the diagnosis of prostate cancer based on sextant analysis

Authors

  • Bo Li MS,

    1. College of Engineering, Peking University, Beijing, China, People's Republic of China
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  • Wenchao Cai BS,

    1. Department of Radiology, Peking University First Hospital, Beijing, China, People's Republic of China
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  • Dongjiao Lv PhD,

    1. College of Engineering, Peking University, Beijing, China, People's Republic of China
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  • Xuemei Guo MD,

    1. Department of Radiology, Peking University First Hospital, Beijing, China, People's Republic of China
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  • Jue Zhang PhD,

    Corresponding author
    1. College of Engineering, Peking University, Beijing, China, People's Republic of China
    2. Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China, People's Republic of China
    • College of Engineering, Peking University, Yiheyuan Road No. 5, Beijing, 100871, China
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  • Xiaoying Wang MD,

    Corresponding author
    1. Department of Radiology, Peking University First Hospital, Beijing, China, People's Republic of China
    2. Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China, People's Republic of China
    • Department of Radiology, Peking University First Hospital, Xishiku Street No. 8, Xicheng District, Beijing, 100034, China
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  • Jing Fang PhD

    1. College of Engineering, Peking University, Beijing, China, People's Republic of China
    2. Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China, People's Republic of China
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Abstract

Purpose:

To evaluate apparent diffusion coefficient (ADC) value, metabolic ratio ((Cho + Cr)/Cit) and the combination of the two in identifying prostate malignant regions.

Materials and Methods:

Fifty-six consecutive patients with prostate biopsy results were retrospectively recruited in this study. Transrectal ultrasound-guided (TRUS) systemic prostate biopsies were used as a standard of reference. Mean ADC value and mean metabolic ratio (MMR) were calculated within each benign sextant region or malignant region. The efficiency of these two indices in prostate cancer (PCa) diagnosis is estimated in Fisher linear discriminant analysis (FLDA). The area under the receiver operating characteristic (ROC) curve was used to evaluate the distinguishing capacity of mean ADC, MMR, and the combination of the two in differentiating between noncancerous and cancerous cases.

Results:

There were significant differences for mean ADC value and MMR between malignant and benign regions. Weights of mean ADC value obtained by FLDA were much higher than those of MMR. In differentiating malignant regions, both ADC alone and combined ADC and metabolic ratio performed significantly better than MMR alone. However, accuracy improvements were not significant by using combined ADC and MMR than ADC alone.

Conclusion:

DWI is more efficient than MR spectroscopic (MRS) in the detection of PCa in this study. Combined ADC and MMR performed significantly better than MMR alone in distinguishing malignant from benign region in prostate peripheral zone. J. Magn. Reson. Imaging 2013;37:194–200. © 2012 Wiley Periodicals, Inc.

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