Adipose tissue MRI for quantitative measurement of central obesity
Article first published online: 10 OCT 2012
Copyright © 2012 Wiley Periodicals, Inc.
Journal of Magnetic Resonance Imaging
Volume 37, Issue 3, pages 707–716, March 2013
How to Cite
Poonawalla, A. H., Sjoberg, B. P., Rehm, J. L., Hernando, D., Hines, C. D., Irarrazaval, P. and Reeder, S. B. (2013), Adipose tissue MRI for quantitative measurement of central obesity. J. Magn. Reson. Imaging, 37: 707–716. doi: 10.1002/jmri.23846
- Issue published online: 15 FEB 2013
- Article first published online: 10 OCT 2012
- Manuscript Accepted: 29 AUG 2012
- Manuscript Received: 14 SEP 2011
- National Institutes of Health (NIH). Grant Numbers: R01 DK083380, R01 DK088925, RC1 EB010384
- Hartwell Foundation
- Coulter Foundation
- adipose tissue;
- body mass index;
- metabolic syndrome;
- central obesity
To validate adipose tissue magnetic resonance imaging (atMRI) for rapid, quantitative volumetry of visceral adipose tissue (VAT) and total adipose tissue (TAT).
Materials and Methods:
Data were acquired on normal adults and clinically overweight girls with Institutional Review Board (IRB) approval/parental consent using sagittal 6-echo 3D-spoiled gradient-echo (SPGR) (26-sec single-breath-hold) at 3T. Fat-fraction images were reconstructed with quantitative corrections, permitting measurement of a physiologically based fat-fraction threshold in normals to identify adipose tissue, for automated measurement of TAT, and semiautomated measurement of VAT. TAT accuracy was validated using oil phantoms and in vivo TAT/VAT measurements validated with manual segmentation. Group comparisons were performed between normals and overweight girls using TAT, VAT, VAT-TAT-ratio (VTR), body-mass-index (BMI), waist circumference, and waist-hip-ratio (WHR).
Oil phantom measurements were highly accurate (<3% error). The measured adipose fat-fraction threshold was 96% ± 2%. VAT and TAT correlated strongly with manual segmentation (normals r2 ≥ 0.96, overweight girls r2 ≥ 0.99). VAT segmentation required 30 ± 11 minutes/subject (14 ± 5 sec/slice) using atMRI, versus 216 ± 73 minutes/subject (99 ± 31 sec/slice) manually. Group discrimination was significant using WHR (P < 0.001) and VTR (P = 0.004).
The atMRI technique permits rapid, accurate measurements of TAT, VAT, and VTR. J. Magn. Reson. Imaging 2013;37:707–716. © 2012 Wiley Periodicals, Inc.