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Long echo time proton magnetic resonance spectroscopy for estimating relative measures of lipid unsaturation at 3 T

Authors

  • Alice Troitskaia,

    1. Department of Oncology, University of Alberta, Edmonton, Alberta, Canada
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  • B. Gino Fallone PhD,

    1. Department of Oncology, University of Alberta, Edmonton, Alberta, Canada
    2. Department of Medical Physics, Cross Cancer Institute, Edmonton, Alberta, Canada
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  • Atiyah Yahya PhD

    Corresponding author
    1. Department of Oncology, University of Alberta, Edmonton, Alberta, Canada
    2. Department of Medical Physics, Cross Cancer Institute, Edmonton, Alberta, Canada
    • Department of Medical Physics, Cross Cancer Institute, 11560 University Ave., Edmonton, Alberta, Canada T6G 1Z2
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Abstract

Purpose:

To examine the behavior of lipid olefinic and diallylic resonances as a function of PRESS (point resolved spectroscopy) echo time (TE) to determine an optimal long TE value for their measurement at 3 T.

Materials and Methods:

Experiments were conducted on nine oils (almond, canola, cod liver, corn, linseed, peanut, sesame, sunflower, and walnut oil) and on vertebral and tibial bone marrow in vivo at 3 T. The methylene (or methyl + methylene), diallylic, and olefinic resonances were measured with PRESS with multiple TEs.

Results:

J-coupling evolution effects on the olefinic and diallylic peaks appeared to be minimized when TE = 200 msec. The TE = 200 msec olefinic/methylene and diallylic/methylene peak area ratios calculated for each oil correlated well with ratios deduced from oil compositions in the literature (R2 = 0.92 and 0.98 for the olefinic and diallylic protons, respectively). In addition, the relative amounts of bone marrow unsaturation of vertebral and tibial bone marrow inferred from the TE = 200 msec olefinic/(methyl + methylene) peak area ratio agreed with values estimated from the literature.

Conclusion:

A PRESS sequence with a long TE value of 200 msec is suitable for determining relative amounts of lipid unsaturation at 3 T. J. Magn. Reson. Imaging 2013;37:944–949. © 2012 Wiley Periodicals, Inc.

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