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Enhancement of the liver and pancreas in the hepatic arterial dominant phase: Comparison of hepatocyte-specific MRI contrast agents, gadoxetic acid and gadobenate dimeglumine, on 3 and 1.5 tesla MRI in the same patient

Authors

  • Hee Jin Kim MD,

    1. Department of Radiology, University of North Carolina at Chapel Hill, CB 7510 – 2001 Old Clinic Bldg., Chapel Hill, North Carolina, USA
    2. Department of Radiology, Eulji University Hospital, Seo-gu, Daejeon, Korea
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  • Bong Soo Kim MD,

    1. Department of Radiology, University of North Carolina at Chapel Hill, CB 7510 – 2001 Old Clinic Bldg., Chapel Hill, North Carolina, USA
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  • Mi Jeong Kim MS,

    1. Department of Radiology, University of North Carolina at Chapel Hill, CB 7510 – 2001 Old Clinic Bldg., Chapel Hill, North Carolina, USA
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  • Seong Hyun Kim MD,

    1. Department of Radiology, University of North Carolina at Chapel Hill, CB 7510 – 2001 Old Clinic Bldg., Chapel Hill, North Carolina, USA
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  • Rafael O.P. de Campos MD,

    1. Department of Radiology, University of North Carolina at Chapel Hill, CB 7510 – 2001 Old Clinic Bldg., Chapel Hill, North Carolina, USA
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  • Mateus Hernandes MD,

    1. Department of Radiology, University of North Carolina at Chapel Hill, CB 7510 – 2001 Old Clinic Bldg., Chapel Hill, North Carolina, USA
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  • Richard C. Semelka MD

    Corresponding author
    1. Department of Radiology, University of North Carolina at Chapel Hill, CB 7510 – 2001 Old Clinic Bldg., Chapel Hill, North Carolina, USA
    • Department of Radiology, UNC at Chapel Hill, CB 7510 – 2001 Old Clinic Bldg., Chapel Hill, NC 27599-7510
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Abstract

Purpose:

To evaluate the relative enhancement of liver, pancreas, focal nodular hyperplasia (FNH), pancreas-to-liver index, and FNH-to-liver index in the hepatic arterial dominant phase (HADP) after injection of hepatocyte-specific MRI contrast agents, gadoxetic acid and gadobenate dimeglumine, on 3 and 1.5 Tesla (T) MRI in the same patient.

Materials and Methods:

The MRI database was retrospectively searched to identify consecutive patients who underwent abdominal MRI at 3T and 1.5T systems, using both 0.025 mmol/kg gadoxetic acid-enhanced and 0.05 mmol/kg gadobenate dimeglumine-enhanced MRI at the same magnetic strength field system. 22 patients were identified, 10 were scanned at 3T system and 12 at 1.5T system. The enhancement of liver, pancreas, and FNH was evaluated quantitatively on MR images.

Results:

The relative enhancement of liver in HADP in the gadobenate dimeglumine-enhanced group in all subjects was significantly higher than that in gadoxetic acid-enhanced group (P = 0.023). The gadobenate dimeglumine-enhanced group in HADP had better relative enhancement of pancreas and FNH, pancreas-to-liver index, and FNH-to-liver index than gadoxetic acid-enhanced group, but the difference was not statistically significant.

Conclusion:

The 0.05 mmol/kg gadobenate dimeglumine-enhanced abdominal MRI studies at 3T and 1.5T MR systems are superior in relative enhancement of the liver in HADP to 0.025 mmol/kg gadoxetic acid-enhanced MRI. This type of assessment may provide comparative effectiveness data. J. Magn. Reson. Imaging 2013;37:903–908. © 2012 Wiley Periodicals, Inc.

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