In vivo validation of 4D flow MRI for assessing the hemodynamics of portal hypertension
Article first published online: 12 NOV 2012
Copyright © 2012 Wiley Periodicals, Inc.
Journal of Magnetic Resonance Imaging
Volume 37, Issue 5, pages 1100–1108, May 2013
How to Cite
Roldán-Alzate, A., Frydrychowicz, A., Niespodzany, E., Landgraf, B. R., Johnson, K. M., Wieben, O. and Reeder, S. B. (2013), In vivo validation of 4D flow MRI for assessing the hemodynamics of portal hypertension. J. Magn. Reson. Imaging, 37: 1100–1108. doi: 10.1002/jmri.23906
- Issue published online: 17 APR 2013
- Article first published online: 12 NOV 2012
- Manuscript Accepted: 25 SEP 2012
- Manuscript Received: 18 APR 2012
- National Institutes of Health. Grant Numbers: R01 DK083380, R01 DK088925, RC1 EB010384, R01HL072260
- University of Wisconsin Radiology R&D Committee
- GE Healthcare
- 4D Flow MRI;
- hepatic hemodynamics;
- portal hypertension
To implement and validate in vivo radial 4D flow MRI for quantification of blood flow in the hepatic arterial, portal venous, and splanchnic vasculature of healthy volunteers and patients with portal hypertension.
Materials and Methods:
Seventeen patients with portal hypertension and seven subjects with no liver disease were included in this Health Insurance Portability and Accountability Act (HIPAA)-compliant and Institutional Review Board (IRB)-approved study. Exams were conducted at 3T using a 32-channel body coil with large volumetric coverage and 1.4 mm isotropic true spatial resolution. Using postprocessing software, cut-planes orthogonal to vessels were used to quantify flow (L/min) in the hepatic and splanchnic vasculature.
Flow quantification was successful in all cases. Portal vein and supraceliac aorta flow demonstrated high variability among patients. Measurements were validated indirectly using internal consistency at three different locations within the portal vein (error = 4.2 ± 3.9%) and conservation of mass at the portal confluence (error = 5.9 ± 2.5%) and portal bifurcation (error = 5.8 ± 3.1%).
This work demonstrates the feasibility of radial 4D flow MRI to quantify flow in the hepatic and splanchnic vasculature. Flow results agreed well with data reported in the literature, and conservation of mass provided indirect validation of flow quantification. Flow in patients with portal hypertensions demonstrated high variability, with patterns and magnitude consistent with the hyperdynamic state that commonly occurs in portal hypertension. J. Magn. Reson. Imaging 2013;37:1100–1108. © 2012 Wiley Periodicals, Inc.