Targeted biopsy based on ADC map in the detection and localization of prostate cancer: A feasibility study
Article first published online: 16 NOV 2012
Copyright © 2012 Wiley Periodicals, Inc.
Journal of Magnetic Resonance Imaging
Volume 37, Issue 5, pages 1168–1177, May 2013
How to Cite
Watanabe, Y., Nagayama, M., Araki, T., Terai, A., Okumura, A., Amoh, Y., Ishimori, T., Nakashita, S. and Dodo, Y. (2013), Targeted biopsy based on ADC map in the detection and localization of prostate cancer: A feasibility study. J. Magn. Reson. Imaging, 37: 1168–1177. doi: 10.1002/jmri.23908
- Issue published online: 17 APR 2013
- Article first published online: 16 NOV 2012
- Manuscript Accepted: 25 SEP 2012
- Manuscript Received: 20 JUN 2011
- magnetic resonance imaging;
- prostate cancer;
- targeted biopsy;
- transition zone;
- diffusion-weighted imaging;
- apparent diffusion coefficient
To investigate the feasibility of targeted biopsy based on an apparent diffusion coefficient (ADC) map in the detection and localization of prostate cancer.
Materials and Methods:
This study included 288 consecutive patients with high or increasing serum prostate-specific antigen (PSA) levels who underwent prostatic magnetic resonance imaging (MRI) examination with an ADC map. Four core-targeted biopsies of low ADC lesions were performed under transrectal-ultrasound guidance with reference to ADC map. The positive predictive values (PPVs) of low ADC lesions were calculated and compared for the peripheral zone (PZ), transition zone (TZ), and anterior portion, respectively. Comparisons of ADC values and sizes between malignant and nonmalignant lesions were also performed.
A total of 313 low ADC lesions were detected in 195 patients and sampled by targeted biopsies. The PPVs were 55.3% (95% confidence interval [CI]: 50–61) in total, 61.0% (95% CI: 53–69) for PZ, 50.6% (95% CI: 43–58) for TZ, and 90.9% (95% CI: 81–100) for the anterior portion. The most common nonmalignant pathology of low ADC lesions was hyperplasia, followed by chronic prostatitis. There were significant differences in ADC values and sizes between malignant and nonmalignant low ADC lesions.
Targeted biopsies could be capable of detecting cancers well wherever they may be in the prostate, although the PPVs varied depending on the location of low ADC lesions. J. Magn. Reson. Imaging 2013;37:1168–1177. © 2012 Wiley Periodicals, Inc.