Magnetic resonance elastography of liver in healthy asians: Normal liver stiffness quantification and reproducibility assessment
Article first published online: 2 OCT 2013
Copyright © 2013 Wiley Periodicals, Inc.
Journal of Magnetic Resonance Imaging
Volume 39, Issue 1, pages 1–8, January 2014
How to Cite
Venkatesh, S. K., Wang, G., Teo, L. L.S. and Ang, B. W.L. (2014), Magnetic resonance elastography of liver in healthy asians: Normal liver stiffness quantification and reproducibility assessment. J. Magn. Reson. Imaging, 39: 1–8. doi: 10.1002/jmri.24084
- Issue published online: 12 DEC 2013
- Article first published online: 2 OCT 2013
- Manuscript Accepted: 24 JAN 2013
- Manuscript Received: 20 FEB 2012
- Individual Research Grant from National Medical Research Council, Singapore
- magnetic resonance elastography;
- liver stiffness measurement;
- normal healthy subjects;
To determine normal liver stiffness values evaluated with magnetic resonance elastography (MRE) in healthy normal Asian volunteers and assess its reproducibility.
Materials and Methods
Liver stiffness was evaluated with MRE in 41 healthy Asians (23 females, 18 males; mean age, 41.8 years, and mean body mass index [BMI], 23.4 kg/m2) on a 1.5T clinical scanner. The correlations between mean liver stiffness and age, gender, BMI, and fat fraction percentage of the liver were studied. Another 12 volunteers underwent liver MRE exams on two separate days 4–6 weeks apart under similar conditions for reproducibility assessment. Intraclass correlation coefficient (ICC) analysis was performed and within-subject coefficient of variation (CV) of stiffness was estimated.
The mean ± standard deviation (SD) of liver stiffness in normal healthy Asian subjects was 2.09 ± 0.22 kPa (95% confidence interval [CI], 2.04–2.15 kPa; range 1.68–2.48 kPa). The mean liver stiffness did not significantly correlate with age, gender, BMI, or fat content of the liver. The ICC for mean liver stiffness was 0.90 (95% CI, 0.78–0.96) and CV ranged from 2.2%–11.4%.
The liver stiffness in normal Asians is not affected by age, gender, BMI, or fat content. Liver stiffness with MRE is highly reproducible. J. Magn. Reson. Imaging 2014;39:1–8. © 2013 Wiley Periodicals, Inc.