Contrast enhanced MR venography with gadofosveset trisodium: Evaluation of the intracranial and extracranial venous system
Article first published online: 22 NOV 2013
Copyright © 2013 Wiley Periodicals, Inc.
Journal of Magnetic Resonance Imaging
How to Cite
Kramer, L. A., Cohen, A. M., Hasan, K. M., Heimbigner, J. H., Barreto, A. D., Brod, S. A., Narayana, P. A. and Wolinsky, J. S. (2013), Contrast enhanced MR venography with gadofosveset trisodium: Evaluation of the intracranial and extracranial venous system. J. Magn. Reson. Imaging. doi: 10.1002/jmri.24409
- Article first published online: 22 NOV 2013
- Manuscript Accepted: 9 AUG 2013
- Manuscript Received: 20 JUN 2013
- National Multiple Sclerosis Society. Grant Number: RC 1019-A-5
- the National Center for Research Resources. Grant Number: UL1 RR024148
- gadofosveset trisodium;
- multiple sclerosis;
To demonstrate the efficacy of contrast enhanced magnetic resonance venography (CEMRV) using gadofosveset trisodium in the comprehensive evaluation of the intracranial and extracranial venous system.
Materials and Methods
Temporal signal decay, in-plane saturation and flow artifacts were assessed in an institutional review board approved, HIPAA compliant CEMRV study of 99 subjects. In a 39 subject subset, percent diameter narrowing of the internal jugular (IJ), brachiocephalic and azygous veins were coded according to the following ordinal grades for both catheter venography (CV) and CEMRV: grade 0 ≤ 50%, grade 1 >50% and ≤ 75%, grade 2 >75% and <100% and grade 3 = 100% and compared with pressure gradient measurements obtained during CV.
There was no significant signal decay, in-plane saturation or flow artifacts identified on CEMRV or hemodynamically significant pressure gradients identified on CV. All brachiocephalic and azygous veins had matched grade 0 narrowing on both modalities. Discrepancy between modalities occurred in the IJ veins at the level of thyroid gland where 15% of IJ veins had CEMRV grade ≥ 1 narrowing compared with 4% for CV or below the thyroid gland where 5% of IJ veins had CEMRV grade ≥ 1 narrowing compared with 20% for CV. There was fair agreement (κ = 0.24) between modalities for grade of narrowing in the combined data set of all coded veins.
CEMRV using gadofosveset trisodium is accurate in the evaluation of the venous system. J. Magn. Reson. Imaging 2013;. © 2013 Wiley Periodicals, Inc.