Mass spectrometry of selective androgen receptor modulators
Article first published online: 2 JUN 2008
Copyright © 2008 John Wiley & Sons, Ltd.
Journal of Mass Spectrometry
Special Issue: Sports Doping Explored
Volume 43, Issue 7, pages 865–876, July 2008
How to Cite
Thevis, M. and Schänzer, W. (2008), Mass spectrometry of selective androgen receptor modulators. J. Mass Spectrom., 43: 865–876. doi: 10.1002/jms.1438
- Issue published online: 24 JUN 2008
- Article first published online: 2 JUN 2008
- Manuscript Accepted: 1 MAY 2008
- Manuscript Received: 28 MAR 2008
- mass spectrometry;
Nonsteroidal selective androgen receptor modulators (SARMs) are an emerging class of drugs for treatment of various diseases including osteoporosis and muscle wasting as well as the correction of age-related functional decline such as muscle strength and power. Several SARMs, which have advanced to preclinical and clinical trials, are composed of diverse chemical structures including arylpropionamide-, bicyclic hydantoin-, quinoline-, and tetrahydroquinoline-derived nuclei. Since January 2008, SARMs have been categorized as anabolic agents and prohibited by the World Anti-Doping Agency (WADA). Suitable detection methods for these low-molecular weight drugs were based on mass spectrometric approaches, which necessitated the elucidation of dissociation pathways in order to characterize and identify the target analytes in doping control samples as well as potential metabolic products and synthetic analogs. Fragmentation patterns of representatives of each category of SARMs after electrospray ionization (ESI) and collision-induced dissociation (CID) as well as electron ionization (EI) are summarized. The complexity and structural heterogeneity of these drugs is a daunting challenge for detection methods. Copyright © 2008 John Wiley & Sons, Ltd.