Fragmentation pathways of metopimazine and its metabolite using ESI-MSn, HR-MS and H/D exchange
Article first published online: 5 AUG 2010
Copyright © 2010 John Wiley & Sons, Ltd.
Journal of Mass Spectrometry
Volume 45, Issue 10, pages 1121–1129, October 2010
How to Cite
Hubert-Roux, M., Bounoure, F., Skiba, M., Bozec, P., Churlaud, F. and Lange, C. M. (2010), Fragmentation pathways of metopimazine and its metabolite using ESI-MSn, HR-MS and H/D exchange. J. Mass Spectrom., 45: 1121–1129. doi: 10.1002/jms.1790
- Issue published online: 5 AUG 2010
- Article first published online: 5 AUG 2010
- Manuscript Accepted: 5 JUL 2010
- Manuscript Received: 10 FEB 2010
Metopimazine (MPZ) is a phenothiazine derivative used to prevent emesis during chemotherapy where few structural analysis of the aforementioned compound have been described in the literature. Thus, this work reports, for the first time, the detailed study of fragmentation pathways of MPZ and its metabolite (AMPZ) using electrospray ionization (EI) with multistage mass spectrometry (ESI-MSn) in positive-ion mode. The structures of 21 product ions were identified and their accurate masses were determined using high resolution mass spectrometry (HRMS) experiments. Characteristic product ions of these two phenothiazine derivatives are more particularly displayed along with differences between their relative abundances and their structures checked by H/D exchange experiments. Copyright © 2010 John Wiley & Sons, Ltd.