This article is part of the Journal of Mass Spectrometry special issue entitled “2nd MS Food Day” edited by Gianluca Giorgi.
Rapid and facile detection of four date rape drugs in different beverages utilizing proton transfer reaction mass spectrometry (PTR-MS)†
Article first published online: 6 SEP 2012
Copyright © 2012 John Wiley & Sons, Ltd.
Journal of Mass Spectrometry
Special Issue: 2nd MS Food Day
Volume 47, Issue 9, pages 1092–1097, September 2012
How to Cite
Jürschik, S., Agarwal, B., Kassebacher, T., Sulzer, P., Mayhew, C. A. and Märk, T. D. (2012), Rapid and facile detection of four date rape drugs in different beverages utilizing proton transfer reaction mass spectrometry (PTR-MS). J. Mass Spectrom., 47: 1092–1097. doi: 10.1002/jms.2993
- Issue published online: 6 SEP 2012
- Article first published online: 6 SEP 2012
- Manuscript Accepted: 20 MAR 2012
- Manuscript Revised: 22 FEB 2012
- Manuscript Received: 13 JAN 2012
- food safety;
- rape drug detection;
- contamination monitoring;
- drink spiking;
- proton transfer reaction
In this work, we illustrate the application of proton transfer reaction mass spectrometry (PTR-MS) in the field of food and drink safety. We present proof-of-principle measurements of four different drinks (water, tea, red wine and white wine) each spiked separately with four different date rape drugs (chloral hydrate, tricholorethanol, γ-butyrolactone and butanediol). At first, the ideal PTR-MS operating conditions (reduced electric field strength and monitoring the most abundant [fragment] ion) for detection of the drugs were determined utilizing a time-of-flight-based PTR-MS instrument. We then dissolved small quantities of the drugs (below the activation threshold for effects on humans) into the various types of drinks and detected them using a quadrupole-based PTR-MS instrument via two different sampling methods: (1) dynamic headspace sampling and (2) direct liquid injection. Both methods have their advantages and drawbacks. Only with dynamic headspace sampling can rape drug contaminations be detected within a timeframe of seconds, and therefore, this method is the most promising use of PTR-MS as a fast, sensitive and selective monitor for the detection of food and drink contamination. Copyright © 2012 John Wiley & Sons, Ltd.