Perforated dried blood spot accurate microsampling: the concept and its applications in toxicokinetic sample collection

Dried blood spots can be a convenient and ethical means of sampling when analyzing compounds in blood. As with any analytical technique, success of the resulting analyses hinge on the precision and accuracy of sample collection, handling and extraction. In this Special Feature, a new method for dried blood spot sampling is described and examined for its' potential to eliminate sources of cross-contamination and to offer higher sampling reproducibility compared to traditional dried blood spot techniques.