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Ion/molecule reactions in a miniature RIT mass spectrometer

  1. Huanwen Chen1,
  2. Ruifeng Xu2,
  3. Hao Chen1,
  4. R. Graham Cooks1,*,
  5. Zheng Ouyang1,*

Article first published online: 28 OCT 2005

DOI: 10.1002/jms.924

Issue

Journal of Mass Spectrometry

Journal of Mass Spectrometry

Volume 40, Issue 11, pages 1403–1411, November 2005

Additional Information

How to Cite

Chen, H., Xu, R., Chen, H., Cooks, R. G. and Ouyang, Z. (2005), Ion/molecule reactions in a miniature RIT mass spectrometer. Journal of Mass Spectrometry, 40: 1403–1411. doi: 10.1002/jms.924

Author Information

  1. 1

    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA

  2. 2

    National Research Center for Certified Reference Materials, Beijing, 100013, China

*Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.

Publication History

  1. Issue published online: 9 NOV 2005
  2. Article first published online: 28 OCT 2005
  3. Manuscript Accepted: 1 AUG 2005
  4. Manuscript Received: 31 MAY 2005

Funded by

  • Purdue Research Foundation Trask Fund, DETRA. Grant Number: (N00164-00-C-0047).
  • National Science Foundation. Grant Number: (CHE 04-12782).

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Keywords:

  • mass spectrometry;
  • miniaturization;
  • rectilinear ion trap;
  • ion/molecule reaction;
  • phosphonium ion;
  • dimethyl methyl phosphonate (DMMP)

Abstract

Ion/molecule reactions were explored in a newly developed miniature mass spectrometer fitted with a rectilinear ion trap (RIT) mass analyzer. The tandem mass spectrometry performance of this instrument is demonstrated using collision induced dissociation (CID) and ion/molecule reactions. The latter includes Eberlin transacetalization reactions and electrophilic additions. Selective detection of the chemical warfare simulant dimethyl methyl phosphonate (DMMP) was achieved through selective Eberlin reactions of its characteristic phosphonium fragment ion CH3OP+(O)CH3 (m/z 93), with 1,4-dioxane or 1,3-dioxolane. Efficient adduct formation as a result of electrophilic attack by the phosphonium ion on various nucleophilic reagents, including 1,1,3,3-tetramethyl urea, methanesulfonic acid methyl ester, dimethyl sulfoxide and methyl salicylate, was also observed using the RIT device. The product ions of these reactions were analyzed using CID and the characteristic fragmentation patterns of the ionic addition products were recorded using multiple-stage experiments in the miniature RIT instrument. This study clearly demonstrates that a small, home-built, miniature RIT mass spectrometer can be used to perform analytically useful ion/molecule reactions and also that instruments like this have the potential to provide a portable platform for in situ detection of organophosphorus esters and related compounds with high specificity using tandem mass spectrometry. Copyright © 2005 John Wiley & Sons, Ltd.

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