Previous publications have appeared under the name Ana M. Cardoso.
Interactions of cationic porphyrins with double-stranded oligodeoxynucleotides: a study by electrospray ionisation mass spectrometry
Article first published online: 1 NOV 2005
Copyright © 2005 John Wiley & Sons, Ltd.
Journal of Mass Spectrometry
Volume 40, Issue 11, pages 1439–1447, November 2005
How to Cite
Ramos, C. I. V., Barros, C. M., Fernandes, A. M., Santana-Marques, M. G., Correia, A. J. F., Tomé, J. P. C., Carrilho, M. d. C. T., Faustino, M. A. F., Tomé, A. C., Neves, M. G. P. M. S. and Cavaleiro, J. A. S. (2005), Interactions of cationic porphyrins with double-stranded oligodeoxynucleotides: a study by electrospray ionisation mass spectrometry. J. Mass Spectrom., 40: 1439–1447. doi: 10.1002/jms.936
- Issue published online: 9 NOV 2005
- Article first published online: 1 NOV 2005
- Manuscript Accepted: 8 SEP 2005
- Manuscript Received: 22 MAR 2005
- FCT (Fundação para a Ciência e Tecnologia). Grant Number: POCTI/42883/QI/2001.
- non-covalent adducts;
- cationic porphyrins;
- outside binding
Electrospray ionisation mass spectrometry (ESI-MS), electrospray ionisation tandem mass spectrometry (ESI-MS/MS) and Ultraviolet-visible (UV–vis) spectroscopy were used to investigate the non-covalent interactions between small oligonucleotide duplexes with the GC motif and a group of cationic meso(N-methylpyridynium-4-yl)porphyrins (four free bases with one to four positive charges, and the zinc complex of the tetracationic free base).
The results obtained point to outside binding of the porphyrins, with the binding strength increasing with the number of positive charges. Fragmentations involving losses from both chains were observed for the porphyrins with N-methylpyridinium-4-yl groups in opposite meso positions. Copyright © 2005 John Wiley & Sons, Ltd.