Journal of Mass Spectrometry

Cover image for Vol. 47 Issue 11

November 2012

Volume 47, Issue 11

Pages 1395–1535

  1. Special feature: perspectives

    1. Top of page
    2. Special feature: perspectives
    3. Research articles
    4. Special feature: perspectives
    5. JMS letters
    6. Research articles
    1. Direct imaging of single cells and tissue at sub-cellular spatial resolution using transmission geometry MALDI MS (page i)

      Andre Zavalin, Erik M. Todd, Patrick D. Rawhouser, Junhai Yang, Jeremy L. Norris and Richard M. Caprioli

      Version of Record online: 13 NOV 2012 | DOI: 10.1002/jms.3132

      Thumbnail image of graphical abstract

      Discussions about MALDI imaging frequently turn to the topic of spatial resolution and the eff orts of some researchers in the field to push towards routine imaging of tissue sections at a cellular scale. Some factors that limit resolution are, the size of the focused desorption laser beam and analyte delocalization from the solution-based sample preparation. With solvent-free matrix application techniques analyte delocalization is less of a concern and the size of the focused laser is the major limiter of spatial resolution. In the Special Feature, Professor Caprioli and co-workers at Vanderbilt University demonstrate a new instrumental approach for improving spatial resolution. They have modifi ed a MALDI-TOF system to use transmission-mode geometry, in which the desorption laser is focused onto the matrix crystals from behind and through the target and sample rather than conventional front-side illumination where the laser is focused onto the crystals directly. They show that by moving the laser source behind the sample target, they can optimize the laser focus to achieve cellular resolution for MALDI imaging.

  2. Research articles

    1. Top of page
    2. Special feature: perspectives
    3. Research articles
    4. Special feature: perspectives
    5. JMS letters
    6. Research articles
    1. Detection of buffalo mozzarella adulteration by an ultra-high performance liquid chromatography tandem mass spectrometry methodology (pages 1407–1414)

      Rosita Russo, Valeria Severino, Alberto Mendez, Josep Lliberia, Augusto Parente and Angela Chambery

      Version of Record online: 29 OCT 2012 | DOI: 10.1002/jms.3064

    2. Surfactant protein B amount and kinetics in newborn infants: an optimized procedure (pages 1415–1419)

      Manuela Simonato, Aldo Baritussio, Luca Vedovelli, Giulia Lamonica, Virgilio Paolo Carnielli and Paola Elisa Cogo

      Version of Record online: 29 OCT 2012 | DOI: 10.1002/jms.3065

    3. Analysis of chloroquine and metabolites directly from whole-body animal tissue sections by liquid extraction surface analysis (LESA) and tandem mass spectrometry (pages 1420–1428)

      Whitney B. Parson, Stormy L. Koeniger, Robert W. Johnson, Jamie Erickson, Yu Tian, Christopher Stedman, Annette Schwartz, Edit Tarcsa, Roderic Cole and Gary J. Van Berkel

      Version of Record online: 7 NOV 2012 | DOI: 10.1002/jms.3068

    4. Innovative determination of polar organophosphonate pesticides based on high-resolution Orbitrap mass spectrometry (pages 1458–1465)

      Juan Antonio Padilla-Sánchez, Patricia Plaza-Bolaños, Roberto Romero-González, Ángel Grande-Martínez, Earl Michael Thurman and Antonia Garrido-Frenich

      Version of Record online: 29 OCT 2012 | DOI: 10.1002/jms.3107

    5. Study of the efficiency for ion transfer through bent capillaries (pages 1466–1472)

      Tsung-Chi Chen, Wei Xu, Sandilya Garimella and Zheng Ouyang

      Version of Record online: 29 OCT 2012 | DOI: 10.1002/jms.3117

  3. Special feature: perspectives

    1. Top of page
    2. Special feature: perspectives
    3. Research articles
    4. Special feature: perspectives
    5. JMS letters
    6. Research articles
    1. Direct imaging of single cells and tissue at sub-cellular spatial resolution using transmission geometry MALDI MS (pages 1473–1481)

      Andre Zavalin, Erik M. Todd, Patrick D. Rawhouser, Junhai Yang, Jeremy L. Norris and Richard M. Caprioli

      Version of Record online: 7 NOV 2012 | DOI: 10.1002/jms.3108

  4. JMS letters

    1. Top of page
    2. Special feature: perspectives
    3. Research articles
    4. Special feature: perspectives
    5. JMS letters
    6. Research articles
    1. Application of MALDI-MS analysis of Rainforest chemodiversity: a keystone for biodiversity conservation and sustainable use (pages 1482–1485)

      Daniel P. Pavarini, Denise B. da Silva, Carlos A. Carollo, Amanda P. F. Portella, Sabrina R. Latansio-Aidar, Pedro O. Cavalin, Viviane C. Oliveira, Bruno H. P. Rosado, Marcos P. M. Aidar, Vanderlan S. Bolzani, Norberto P. Lopes and Carlos A. Joly

      Version of Record online: 29 OCT 2012 | DOI: 10.1002/jms.3100

    2. Quadrupole mass spectroscopy of neon (pages 1486–1487)

      Sebastian Dahle and Wolfgang Maus-Friedrichs

      Version of Record online: 7 NOV 2012 | DOI: 10.1002/jms.3082

  5. Research articles

    1. Top of page
    2. Special feature: perspectives
    3. Research articles
    4. Special feature: perspectives
    5. JMS letters
    6. Research articles
    1. Gas-phase basicity of 2-furaldehyde (pages 1488–1494)

      Andreina Ricci, Simona Piccolella, Federico Pepi, Alexandros Patsilinakos, Rino Ragno, Stefania Garzoli and Pierluigi Giacomello

      Version of Record online: 7 NOV 2012 | DOI: 10.1002/jms.3058

    2. Study of small chlorine-doped potassium clusters by thermal ionization mass spectrometry (pages 1495–1499)

      F. M. Veljković, J. B. Djustebek, M. V. Veljković, A. A. Perić-Grujić and S. R. Veličković

      Version of Record online: 7 NOV 2012 | DOI: 10.1002/jms.3076

    3. Comprehensive characterization of Annonaceous acetogenins within a complex extract by HPLC-ESI-LTQ-Orbitrap® using post-column lithium infusion (pages 1500–1509)

      Jessica Le Ven, Isabelle Schmitz-Afonso, Guy Lewin, Olivier Laprévote, Alain Brunelle, David Touboul and Pierre Champy

      Version of Record online: 7 NOV 2012 | DOI: 10.1002/jms.3092

    4. Exploring the intrinsic polar [4 + 2+] cycloaddition reactivity of gaseous carbosulfonium and carboxonium ions (pages 1526–1535)

      Muftah M. Basher, Yuri E. Corilo, Regina Sparrapan, Mario Benassi, Rodinei Augusti, Marcos N. Eberlin and José M. Riveros

      Version of Record online: 7 NOV 2012 | DOI: 10.1002/jms.3109

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