Journal of Mass Spectrometry

Cover image for Vol. 47 Issue 12

December 2012

Volume 47, Issue 12

Pages 1554–1671

  1. Special feature: tutorial

    1. Top of page
    2. Special feature: tutorial
    3. Research articles
    4. JMS letter
    5. Research articles
    6. Special feature: tutorial
    7. Application note
    8. Research articles
    9. Erratum
    1. An introduction to hybrid ion trap/time-of-flight mass spectrometry coupled with liquid chromatography applied to drug metabolism studies (page i)

      Zhao-Ying Liu

      Article first published online: 27 DEC 2012 | DOI: 10.1002/jms.3147

      Thumbnail image of graphical abstract

      Metabolism studies play an important role at various stages of drug discovery and development. Liquid chromatography combined with mass spectrometry (LC/MS) is to date most powerful and widely used analytical tool for identifying and quantifying drug metabolites. In this respect, the choice of instrumentation currently available is wide with various sets of strength and weaknesses aff ecting data quality and reliability. In this tutorial special feature article, Dr Zhao-Ying Liu from the College of Veterinary Medicine at the Hunan Agricultural University (Hunan, China) describes one of the latest LC/MS instrumentation design namely a hybrid ion trap/time-of-flight MS coupled with liquid chromatography (LC-IT-TOF-MS). This hybrid MS system has successfully integrated ease of operation, compatibility with LC flow rates and data-dependent MSn with high mass accuracy and mass resolving power for drug metabolism studies. Dr Liu interests are centered on the research and development of LC/MS techniques and instrumentation including data processing for pharmacokinetics and veterinary pharmaceutics.

  2. Research articles

    1. Top of page
    2. Special feature: tutorial
    3. Research articles
    4. JMS letter
    5. Research articles
    6. Special feature: tutorial
    7. Application note
    8. Research articles
    9. Erratum
    1. Peptide peak intensities enhanced by cysteine modifiers and MALDI TOF MS (pages 1546–1553)

      Masoud Zabet-Moghaddam, Aarif L. Shaikh and Satomi Niwayama

      Article first published online: 6 DEC 2012 | DOI: 10.1002/jms.3093

  3. JMS letter

    1. Top of page
    2. Special feature: tutorial
    3. Research articles
    4. JMS letter
    5. Research articles
    6. Special feature: tutorial
    7. Application note
    8. Research articles
    9. Erratum
    1. Clarification of a peak at m/z 1634 from tryptically digested cytochrome c (pages 1576–1581)

      Seongjae Shin, Hyo-Jik Yang, Jae-hyung Kim, Jinhee Kim, Ji-hye Lee, Kyu Hwan Park, Hyun Sik Kim and Jeongkwon Kim

      Article first published online: 22 NOV 2012 | DOI: 10.1002/jms.3119

  4. Research articles

    1. Top of page
    2. Special feature: tutorial
    3. Research articles
    4. JMS letter
    5. Research articles
    6. Special feature: tutorial
    7. Application note
    8. Research articles
    9. Erratum
    1. Characterization of the photodegradation products of metolachlor: structural elucidation, potential toxicity and persistence (pages 1582–1593)

      Sarah Coffinet, Ahmad Rifai, Christophe Genty, Yasmine Souissi, Sophie Bourcier, Michel Sablier and Stéphane Bouchonnet

      Article first published online: 22 NOV 2012 | DOI: 10.1002/jms.3121

    2. Simultaneous quantitation of IC87114, roflumilast and its active metabolite roflumilast N-oxide in plasma by LC-MS/MS: application for a pharmacokinetic study (pages 1612–1619)

      Satheeshmanikandan RS Thappali, Kanthikiran VS Varanasi, Sridhar Veeraraghavan, Swaroop Kumar VS Vakkalanka and Mukkanti K

      Article first published online: 22 NOV 2012 | DOI: 10.1002/jms.3103

  5. Special feature: tutorial

    1. Top of page
    2. Special feature: tutorial
    3. Research articles
    4. JMS letter
    5. Research articles
    6. Special feature: tutorial
    7. Application note
    8. Research articles
    9. Erratum
  6. Application note

    1. Top of page
    2. Special feature: tutorial
    3. Research articles
    4. JMS letter
    5. Research articles
    6. Special feature: tutorial
    7. Application note
    8. Research articles
    9. Erratum
    1. Separation of isomeric disaccharides by traveling wave ion mobility mass spectrometry using CO2 as drift gas (pages 1643–1647)

      Maíra Fasciotti, Gustavo B. Sanvido, Vanessa G. Santos, Priscila M. Lalli, Michael McCullagh, Gilberto F. de Sá, Romeu J. Daroda, Martin G. Peter and Marcos N. Eberlin

      Article first published online: 6 DEC 2012 | DOI: 10.1002/jms.3089

  7. Research articles

    1. Top of page
    2. Special feature: tutorial
    3. Research articles
    4. JMS letter
    5. Research articles
    6. Special feature: tutorial
    7. Application note
    8. Research articles
    9. Erratum
  8. Erratum

    1. Top of page
    2. Special feature: tutorial
    3. Research articles
    4. JMS letter
    5. Research articles
    6. Special feature: tutorial
    7. Application note
    8. Research articles
    9. Erratum
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